INT277578

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.17
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mef2c) nucleus (Mef2c) DNA binding (Mef2c)
protein complex (Mef2c) cytoplasm (Mef2c)
Anatomy Link Frequency
chondrocyte 2
Mef2c (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 20 92.84 High High
depression 1 41.16 Quite Low
anesthesia 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
cocaine 4 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Acute pain 2 5.00 Very Low Very Low Very Low
Eae 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 8 100.00 Very High Very High Very High
Hypertrophy 21 97.80 Very High Very High Very High
Left Ventricular Hypertrophy 20 96.16 Very High Very High Very High
Fibrosis 20 92.84 High High
Targeted Disruption 11 82.16 Quite High
Convulsion 27 66.76 Quite High
Nociception 9 50.00 Quite Low
Natriuresis 2 44.56 Quite Low
Depression 1 41.16 Quite Low
Adhesions 2 32.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we next examined if depletion of MEF2C could change the expression of PGC-1?
Regulation (change) of Negative_regulation (depletion) of MEF2C
1) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0 Pain Relevance 0
Depletion of MEF2C did not change the left ventricular diameter or fractional shortening (Figure 4B, C).
Neg (not) Regulation (change) of Negative_regulation (Depletion) of MEF2C
2) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.45 Pain Relevance 0.07
Therefore it is highly likely that the expressed HDAC4 1-747 retains its binding to and repression of MEF2C and Runx2 in vivo, explaining the lack of chondrocyte hypertrophy in our mutant mice.
Regulation (retains) of Negative_regulation (repression) of MEF2C in chondrocyte associated with hypertrophy and repression
3) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.73 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox