INT277581

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.47
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hdac4) nucleus (Hdac4) DNA binding (Hdac4)
transcription factor binding (Hdac4) cytoplasm (Hdac4)
Anatomy Link Frequency
neuron 1
dorsal horn 1
Hdac4 (Mus musculus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 2 100.00 Very High Very High Very High
Spinal cord 48 95.96 Very High Very High Very High
Hyperalgesia 17 93.44 High High
cocaine 13 92.20 High High
Inflammation 8 80.32 Quite High
Thermal hyperalgesia 14 77.96 Quite High
Pain 17 60.36 Quite High
Neuronal excitability 3 51.32 Quite High
Analgesic 9 41.04 Quite Low
Acute pain 6 28.32 Quite Low
Disease Link Frequency Relevance Heat
Death 6 97.12 Very High Very High Very High
Hyperalgesia 31 93.44 High High
INFLAMMATION 8 80.32 Quite High
Repression 24 68.36 Quite High
Epilepsy 12 64.44 Quite High
Pain 36 60.36 Quite High
Convulsion 81 52.20 Quite High
Contagious Ecthyma 3 51.52 Quite High
Nociception 45 50.68 Quite High
Targeted Disruption 22 43.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nuclear accumulation of HDAC4 has been implicated in several pathways of regulation of neuronal cell death [30] and in vitro such nuclear accumulation has resulted in cerebellar granule neuron death.
Positive_regulation (accumulation) of HDAC4 in neuron associated with death
1) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.19 Pain Relevance 0.15
If this were the only means for HDAC4 nuclear export, we would expect nuclear accumulation of the protein in HDAC4?
Positive_regulation (accumulation) of HDAC4
2) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.18 Pain Relevance 0.15
OmniBank ES cell clone OST361114 was used to generate HDAC4?
Positive_regulation (generate) of HDAC4
3) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.24 Pain Relevance 0.03
Using immunoblot analysis, we further found that the levels of class IIa HDAC members (HDAC4, 5, 7, 9) in the spinal dorsal horn were upregulated following CFA injection while those of class I HDAC members (HDAC1, 2, 3) remained stable or were slightly reduced.


Positive_regulation (upregulated) of HDAC4 in dorsal horn associated with spinal dorsal horn
4) Confidence 0.31 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2942827 Disease Relevance 0.87 Pain Relevance 0.92

General Comments

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