INT277587

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Context Info
Confidence 0.65
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.43
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mef2c) nucleus (Mef2c) DNA binding (Mef2c)
protein complex (Mef2c) cytoplasm (Mef2c)
Anatomy Link Frequency
nucleus 1
Mef2c (Mus musculus)
Pain Link Frequency Relevance Heat
depression 1 16.56 Low Low
cocaine 4 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Acute pain 2 5.00 Very Low Very Low Very Low
Eae 2 5.00 Very Low Very Low Very Low
nociceptor 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Neuronal excitability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 8 98.32 Very High Very High Very High
Hypertrophy 3 79.88 Quite High
Targeted Disruption 7 57.56 Quite High
Convulsion 27 50.00 Quite Low
Nociception 9 50.00 Quite Low
Depression 1 16.56 Low Low
Epilepsy 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Muscular Spasm 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While HDAC4 by itself lacks nuclear transport capabilities, evidence exists for MEF2 translocating HDAC4 to the nucleus where transcription repression is brought about by recruiting other HDAC's like HDAC1 [8].
Localization (translocating) of MEF2 in nucleus associated with repression
1) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.43 Pain Relevance 0

General Comments

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