INT277591

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Context Info
Confidence 0.77
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 7.77
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hdac4) nucleus (Hdac4) DNA binding (Hdac4)
transcription factor binding (Hdac4) cytoplasm (Hdac4)
Anatomy Link Frequency
chondrocyte 4
brain 1
striatum 1
Hdac4 (Mus musculus)
Pain Link Frequency Relevance Heat
monoamine 2 97.68 Very High Very High Very High
Spinal cord 99 95.88 Very High Very High Very High
GABAergic 2 95.72 Very High Very High Very High
cocaine 81 94.96 High High
Cancer pain 1 92.68 High High
Acute pain 40 92.16 High High
anticonvulsant 1 91.52 High High
Migraine 1 90.20 High High
Analgesic 43 81.84 Quite High
nociceptor 40 81.72 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 145 99.24 Very High Very High Very High
Convulsion 540 99.12 Very High Very High Very High
Nociception 198 98.92 Very High Very High Very High
Repression 162 98.64 Very High Very High Very High
Hypertrophy 60 98.44 Very High Very High Very High
Muscular Spasm 40 93.64 High High
Congenital Anomalies 81 93.24 High High
Cancer Pain 1 92.68 High High
Pain 87 92.16 High High
Epilepsy 80 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, over-expression of HDAC4 resulted in inhibition of chondrocyte hypertrophy with delayed ossification [6].
Gene_expression (over) of HDAC4 in chondrocyte associated with hypertrophy
1) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.27 Pain Relevance 0
Therefore it is highly likely that the expressed HDAC4 1-747 retains its binding to and repression of MEF2C and Runx2 in vivo, explaining the lack of chondrocyte hypertrophy in our mutant mice.
Gene_expression (expressed) of HDAC4 in chondrocyte associated with hypertrophy and repression
2) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.73 Pain Relevance 0
Similar viral vector overexpression of full length HDAC4 in the striatum of mice led to reduced levels of histone H3 acetylation in the tissue and decreased the rewarding effects of cocaine in the place conditioning assay [29].
Gene_expression (overexpression) of HDAC4 in striatum associated with cocaine
3) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0 Pain Relevance 0.17
3.46, P<0.01 t-test); there was no difference in total distance between the males (WT 1665±183.6 cm, HDAC4?
Gene_expression (males) of HDAC4
4) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.53 Pain Relevance 0.18
RT-PCR analysis confirmed both the absence of full length HDAC4 transcript and the presence of a HDAC4-BGEO fusion transcript in the homozygous HDAC4?
Gene_expression (presence) of HDAC4
5) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0 Pain Relevance 0
OmniBank ES cell clone OST361114 was used to generate HDAC4?
Gene_expression (generate) of HDAC4
6) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.24 Pain Relevance 0.03
C mice traveled a greater distance in the OF than WT females (WT 1538±240.5 cm, HDAC4?
Gene_expression (distance) of HDAC4
7) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.48 Pain Relevance 0.21
RT-PCR analysis confirmed both the absence of full length HDAC4 transcript and the presence of a HDAC4-BGEO fusion transcript in the homozygous HDAC4?
Gene_expression (presence) of HDAC4
8) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0 Pain Relevance 0
Some of the HDAC4?
Gene_expression (Some) of HDAC4
9) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 1.03 Pain Relevance 0.07
Thus aa 1-747, retained in our HDAC4?
Gene_expression (retained) of HDAC4
10) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.31 Pain Relevance 0
Western analysis using several HDAC4 antibodies confirmed absence of the full length protein in brain tissue from HDAC4?
Gene_expression (antibodies) of HDAC4 in brain
11) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0 Pain Relevance 0
It is surprising that the low expression of HDAC4?
Gene_expression (expression) of HDAC4
12) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.24 Pain Relevance 0
This mutation (HDAC4?
Gene_expression (mutation) of HDAC4
13) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.05 Pain Relevance 0
The HDAC4?
Gene_expression (The) of HDAC4
14) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.72 Pain Relevance 0.31
There were no differences noted in the HDAC4?
Neg (no) Gene_expression (noted) of HDAC4
15) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.30 Pain Relevance 0.18
Western blot and immuno-precipitation analysis confirm expression of truncated HDAC4 containing N-terminal amino acids 1-747.
Gene_expression (expression) of HDAC4
16) Confidence 0.60 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2720538 Disease Relevance 0.47 Pain Relevance 0
On the other hand, over-expression of HDAC4 resulted in inhibition of chondrocyte hypertrophy with delayed ossification [6].
Gene_expression (expression) of HDAC4 in chondrocyte associated with hypertrophy
17) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.27 Pain Relevance 0
On the other hand, over-expression of HDAC4 resulted in inhibition of chondrocyte hypertrophy with delayed ossification [6].
Gene_expression (-) of HDAC4 in chondrocyte associated with hypertrophy
18) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.27 Pain Relevance 0
These insertions occur prior to two possible alternate transcription start sites (TSS) for HDAC4 in the mouse, (alternate TSS 1 within intron 1 (representative EST BY272035) and alternate TSS 2 within intron 4 (representative mRNA AK029933)) therefore these mutations were not expected to disrupt expression of all isoforms of the HDAC4 gene.
Gene_expression (expression) of HDAC4
19) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.12 Pain Relevance 0
Generation of HDAC4?
Gene_expression (Generation) of HDAC4
20) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.34 Pain Relevance 0.03

General Comments

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