INT277593

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Context Info
Confidence 0.75
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.07
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hdac4) nucleus (Hdac4) DNA binding (Hdac4)
transcription factor binding (Hdac4) cytoplasm (Hdac4)
Anatomy Link Frequency
neuronal 1
brain 1
nucleus 1
Hdac4 (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 16 94.04 High High
depression 4 92.72 High High
Analgesic 8 33.04 Quite Low
Spinal cord 12 16.88 Low Low
Acute pain 8 16.52 Low Low
Eae 8 5.00 Very Low Very Low Very Low
nociceptor 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
analgesia 4 5.00 Very Low Very Low Very Low
Neuronal excitability 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 32 98.56 Very High Very High Very High
Convulsion 108 98.24 Very High Very High Very High
Depression 4 92.72 High High
Death 8 86.24 High High
Hypertrophy 12 79.68 Quite High
Epilepsy 16 79.20 Quite High
Targeted Disruption 28 65.20 Quite High
Nociception 36 50.00 Quite Low
Muscular Spasm 8 37.84 Quite Low
Pain 12 16.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If this were the only means for HDAC4 nuclear export, we would expect nuclear accumulation of the protein in HDAC4?
Localization (export) of HDAC4
1) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.17 Pain Relevance 0.16
While HDAC4 by itself lacks nuclear transport capabilities, evidence exists for MEF2 translocating HDAC4 to the nucleus where transcription repression is brought about by recruiting other HDAC's like HDAC1 [8].
Localization (translocating) of HDAC4 in nucleus associated with repression
2) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.43 Pain Relevance 0
Induction of c-Fos is an early marker of neuronal activity and is a robust marker of seizure activity [25]. c-Fos immunohistochemistry, performed one hour after handling, on brain sections of 5 animals of WT or HDAC4?
Localization (sections) of HDAC4 in neuronal associated with convulsion
3) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 1.47 Pain Relevance 0.05
Western analysis using several HDAC4 antibodies confirmed absence of the full length protein in brain tissue from HDAC4?
Localization (tissue) of HDAC4 in brain
4) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0 Pain Relevance 0

General Comments

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