INT277610

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Context Info
Confidence 0.32
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.78
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx2, Hdac4) DNA binding (Runx2, Hdac4) transcription factor binding (Runx2, Hdac4)
cytoplasm (Runx2, Hdac4) cytosol (Hdac4)
Anatomy Link Frequency
chondrocyte 1
Runx2 (Mus musculus)
Hdac4 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 1 41.64 Quite Low
cocaine 4 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Acute pain 2 5.00 Very Low Very Low Very Low
Eae 2 5.00 Very Low Very Low Very Low
nociceptor 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Neuronal excitability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 8 100.00 Very High Very High Very High
Hypertrophy 3 98.20 Very High Very High Very High
Targeted Disruption 7 82.64 Quite High
Convulsion 27 67.24 Quite High
Nociception 9 50.00 Quite Low
Depression 1 41.64 Quite Low
Epilepsy 4 28.12 Quite Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Muscular Spasm 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore it is highly likely that the expressed HDAC4 1-747 retains its binding to and repression of MEF2C and Runx2 in vivo, explaining the lack of chondrocyte hypertrophy in our mutant mice.
Runx2 Binding (binding) of HDAC4 in chondrocyte associated with hypertrophy and repression
1) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.78 Pain Relevance 0

General Comments

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