INT27762

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Context Info
Confidence 0.70
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 17.67
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EPO) extracellular space (EPO) aging (EPO)
extracellular region (EPO)
Anatomy Link Frequency
blood 2
glial cells 2
jejunum 2
cerebrospinal fluid 2
bone marrow 2
EPO (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 53 99.28 Very High Very High Very High
Inflammation 45 99.24 Very High Very High Very High
dopaminergic neurodegeneration 1 99.04 Very High Very High Very High
medulla 70 91.32 High High
Pain 23 85.32 High High
Substantia nigra 1 75.36 Quite High
Neuropathic pain 3 74.24 Quite High
Nerve growth factor 10 64.88 Quite High
diabetic neuropathy 4 58.08 Quite High
Spinal cord 6 50.00 Quite Low
Disease Link Frequency Relevance Heat
Anaemia 330 99.98 Very High Very High Very High
Hypoxia 204 99.98 Very High Very High Very High
Injury 33 99.74 Very High Very High Very High
INFLAMMATION 50 99.24 Very High Very High Very High
Disease 88 99.14 Very High Very High Very High
Myelodysplastic Syndromes 82 98.56 Very High Very High Very High
Hemorrhage 26 98.16 Very High Very High Very High
Renal Disease 20 97.84 Very High Very High Very High
Inflammatory Bowel Disease 24 97.50 Very High Very High Very High
Malaria 132 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We demonstrate that the relevant axonal injury signal that stimulates EPO production from surrounding glial cells is nitric oxide.
Positive_regulation (stimulates) of Gene_expression (production) of EPO in glial cells associated with injury
1) Confidence 0.70 Published 2004 Journal Ann. Neurol. Section Abstract Doc Link 15470751 Disease Relevance 0.60 Pain Relevance 0.07
Hypoxia induces Epo and Epo receptor expression [14-18].
Positive_regulation (induces) of Gene_expression (expression) of Epo associated with hypoxia
2) Confidence 0.64 Published 2009 Journal Malar J Section Body Doc Link PMC2785829 Disease Relevance 1.32 Pain Relevance 0.26
CONCLUSIONS: After an intravenous infusion of epoetin alpha, radiotherapy and steroids, high concentrations of erythropoietin were detectable in the cerebrospinal fluid.
Positive_regulation (concentrations) of Gene_expression (detectable) of epoetin alpha in cerebrospinal fluid
3) Confidence 0.50 Published 2007 Journal Clin Oncol (R Coll Radiol) Section Body Doc Link 17305256 Disease Relevance 0 Pain Relevance 0
Who should receive recombinant human erythropoietin?
Positive_regulation (receive) of Gene_expression (receive) of erythropoietin
4) Confidence 0.50 Published 1989 Journal Semin. Nephrol. Section Title Doc Link 2669084 Disease Relevance 0.41 Pain Relevance 0
ESAM 2003 already showed increased mean EPO doses compared to ESAM 1998 [11] in all participating countries, certainly explaining most of the improvement of anaemia control.
Positive_regulation (increased) of Gene_expression (doses) of EPO associated with anaemia
5) Confidence 0.50 Published 2008 Journal BMC Nephrol Section Body Doc Link PMC2621153 Disease Relevance 0.35 Pain Relevance 0
Group IP1 received erythropoietin in 20 ml/kg of dialysis fluid, while in group IP2 the hormone was added to only 50 ml of dialysate, irrespective of body weight.
Positive_regulation (received) of Gene_expression (received) of erythropoietin in body associated with body weight
6) Confidence 0.50 Published 1994 Journal Eur. J. Pediatr. Section Abstract Doc Link 7843202 Disease Relevance 0.56 Pain Relevance 0.09
A higher fat mass may stimulate erythropoiesis through increased endogenous erythropoietin synthesis and/or sensitivity via the adipocyte hormone leptin [15,16].
Positive_regulation (increased) of Gene_expression (synthesis) of erythropoietin in adipocyte
7) Confidence 0.47 Published 2008 Journal BMC Nephrol Section Body Doc Link PMC2621153 Disease Relevance 1.08 Pain Relevance 0
Hypoxia induces Epo and Epo receptor expression [14-18].
Positive_regulation (induces) of Gene_expression (expression) of Epo associated with hypoxia
8) Confidence 0.46 Published 2009 Journal Malar J Section Body Doc Link PMC2785829 Disease Relevance 1.32 Pain Relevance 0.26
Why does rhEpo fail to improve maximal oxygen uptake during acute severe hypoxia?
Positive_regulation (improve) of Gene_expression (improve) of rhEpo associated with hypoxia
9) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500186 Disease Relevance 0.77 Pain Relevance 0
Why does rhEpo fail to improve maximal oxygen uptake during acute severe hypoxia?
Positive_regulation (Why) of Gene_expression (fail) of rhEpo associated with hypoxia
10) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500186 Disease Relevance 0.77 Pain Relevance 0
Intra- and inter-individual variability of the epoetin dose
Positive_regulation (variability) of Gene_expression (dose) of epoetin
11) Confidence 0.38 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1578551 Disease Relevance 0.39 Pain Relevance 0
The homeostatic balance is upheld via a sensitive system where hypoxia induces transcription of erythropoietin (Epo), produced by the kidneys.
Positive_regulation (induces) of Gene_expression (produced) of erythropoietin associated with hypoxia
12) Confidence 0.37 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 1.06 Pain Relevance 0
Although anemia in IBD often involves a combination of IDA and the anemia of chronic disease (ACD), IDA remains an important contributor via: (1) decreased iron intake due to avoidance of foods that may exacerbate symptoms of IBD; (2) chronic intestinal bleeding; (3) impaired iron absorption in Crohn’s disease of the duodenum or upper jejunum; and (4) increased erythropoietin response that cannot be matched to the available iron, resulting in ineffective erythropoiesis [2].
Positive_regulation (increased) of Gene_expression (response) of erythropoietin in jejunum associated with inflammatory bowel disease, anaemia, iron-deficiency anemia, hemorrhage, disease and chronic disease
13) Confidence 0.34 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2822907 Disease Relevance 2.13 Pain Relevance 0.04
These inflammatory cytokines can also interfere with endogenous erythropoietin (eEPO) production (Jelkmann et al, 1994) which may contribute further to the anaemia observed in MDS patients.
Positive_regulation (contribute) of Gene_expression (production) of erythropoietin associated with anaemia, inflammation, myelodysplastic syndromes and cytokine
14) Confidence 0.30 Published 2008 Journal British Journal of Haematology Section Body Doc Link PMC2654479 Disease Relevance 1.89 Pain Relevance 0.21
These inflammatory cytokines can also interfere with endogenous erythropoietin (eEPO) production (Jelkmann et al, 1994) which may contribute further to the anaemia observed in MDS patients.
Positive_regulation (contribute) of Gene_expression (production) of eEPO associated with anaemia, inflammation, myelodysplastic syndromes and cytokine
15) Confidence 0.30 Published 2008 Journal British Journal of Haematology Section Body Doc Link PMC2654479 Disease Relevance 1.88 Pain Relevance 0.21
These results demonstrate that vector-mediated EPO production may be used to reverse dopaminergic neurodegeneration in the face of continued toxic insult.


Positive_regulation (mediated) of Gene_expression (production) of EPO in face associated with dopaminergic neurodegeneration
16) Confidence 0.23 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.05 Pain Relevance 0.23
Treatment with rhGH has been shown to reduce protein catabolism,13,14 increase muscle area and strength,14–18 increase erythropoietin synthesis,19 and to improve inflammation status and quality of life.20 A recent 6-month study showed a positive effect of GH treatment on lean body mass and cardiovascular risk factors.21 Furthermore, GH administration is associated with improvements in several nutritional parameters, such as increases in serum insulin-like growth factor-I (IGF-I),13,14,22 serum albumin14 and transferrin,13 and a reduction in blood urea nitrogen.13
Positive_regulation (increase) of Gene_expression (synthesis) of erythropoietin in blood associated with inflammation
17) Confidence 0.19 Published 2007 Journal Clinical Endocrinology Section Body Doc Link PMC2366021 Disease Relevance 0.92 Pain Relevance 0.08
Anemia stimulates the production of erythropoietin with consequent intensive but ineffective expansion of the bone marrow (up 25 to 30 times normal), which in turn causes the typical previously described bone deformities.
Positive_regulation (stimulates) of Gene_expression (production) of erythropoietin in bone marrow associated with anaemia and congenital anomalies
18) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2893117 Disease Relevance 1.17 Pain Relevance 0

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