INT277664

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.50
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EGF, EGFR) signal transduction (EGF, EGFR) extracellular region (EGF, EGFR)
plasma membrane (EGF, EGFR) endosome (EGFR) cell morphogenesis (EGFR)
Anatomy Link Frequency
Gill 2
EGF (Homo sapiens)
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 1 96.64 Very High Very High Very High
Head & Neck Cancer 1 96.52 Very High Very High Very High
Metastasis 2 80.48 Quite High
Cancer 25 79.40 Quite High
Colon Cancer 1 77.84 Quite High
Lung Cancer 9 70.80 Quite High
Non-small-cell Lung Cancer 38 7.60 Low Low
Nicotine Addiction 26 5.00 Very Low Very Low Very Low
Exanthema 20 5.00 Very Low Very Low Very Low
Toxicity 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cetuximab competitively blocks the binding of the EGF and other ligands to the EGFR thus preventing the activation of the downstream TK resulting in growth arrest and apoptosis (Gill et al 1984; Sato et al 1983; Baselga 2000).
Negative_regulation (blocks) of EGF Binding (binding) of EGFR in Gill associated with apoptosis
1) Confidence 0.18 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721286 Disease Relevance 0.50 Pain Relevance 0

General Comments

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