INT277670

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.12
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Stat6) nucleus (Stat6) DNA binding (Stat6)
cytoplasm (Stat6) signal transducer activity (Stat6)
Anatomy Link Frequency
lymphocytes 4
Stat6 (Mus musculus)
Pain Link Frequency Relevance Heat
pruritus 10 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
psoriasis 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Onset of action 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 34 99.96 Very High Very High Very High
Lymphatic System Cancer 102 98.04 Very High Very High Very High
Syndrome 62 95.88 Very High Very High Very High
Solid Tumor 10 85.44 High High
Hematologic Neoplasms 18 84.08 Quite High
Mycosis Fungoides 96 78.48 Quite High
Cancer 116 77.60 Quite High
Disease 42 5.00 Very Low Very Low Very Low
Thrombocytopenia 20 5.00 Very Low Very Low Very Low
Vomiting 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vorinostat at concentrations capable of producing apoptosis, decreased the expression of Stat6 and phosphor-Stat-6 (but not Stat3 and phosphor-Stat3) were seen in CTCL cell lines and peripheral blood lymphocytes from SS patients (Duvic and Zhang 2006).


Negative_regulation (decreased) of Gene_expression (expression) of phosphor-Stat-6 in lymphocytes associated with lymphatic system cancer, syndrome and apoptosis
1) Confidence 0.14 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721288 Disease Relevance 1.06 Pain Relevance 0
Vorinostat at concentrations capable of producing apoptosis, decreased the expression of Stat6 and phosphor-Stat-6 (but not Stat3 and phosphor-Stat3) were seen in CTCL cell lines and peripheral blood lymphocytes from SS patients (Duvic and Zhang 2006).


Negative_regulation (decreased) of Gene_expression (expression) of Stat6 in lymphocytes associated with lymphatic system cancer, syndrome and apoptosis
2) Confidence 0.12 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721288 Disease Relevance 1.05 Pain Relevance 0

General Comments

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