INT277699

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.20
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 4.84
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdgfb) cytoplasm (Pdgfb)
Anatomy Link Frequency
hippocampus 1
Pdgfb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 10 99.96 Very High Very High Very High
ischemia 4 97.92 Very High Very High Very High
Hippocampus 80 96.72 Very High Very High Very High
depression 8 43.52 Quite Low
long-term potentiation 12 5.00 Very Low Very Low Very Low
Osteoarthritis 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
amygdala 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 258 100.00 Very High Very High Very High
Cancer 58 99.36 Very High Very High Very High
Coma 4 98.38 Very High Very High Very High
Cv Unclassified Under Development 4 97.92 Very High Very High Very High
Convulsion 16 97.72 Very High Very High Very High
Ring Chromosomes 20 93.24 High High
Toxicity 8 90.16 High High
Anaemia 2 89.36 High High
Chromosome Aberrations 6 88.48 High High
Pressure And Volume Under Development 2 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant reduction in BDNF protein levels was found only 2 h after the start of the SIS session (Figure 4).
Gene_expression (session) of SIS associated with stress
1) Confidence 0.20 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.81 Pain Relevance 0.14
The levels of acetylated histone H3 at promoters I, IV, and VI were significantly reduced immediately following 2-h SIS, but the reductions were no statistically significant 24 h after the start of the 2-h SIS session (Figure 3A).
Gene_expression (session) of SIS associated with stress
2) Confidence 0.20 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.87 Pain Relevance 0.11
Differential usage of multiple promoters of BDNF is considered to generate region-specific expression and responses to both physiological stimuli such as diurnal rhythm and exercise, and pathophysiological insults such as seizures, ischemia, and hypoglycemic coma.16-18 Recently, Nair et al.,19 using in situ hybridization, demonstrated that a SIS significantly decreased the levels of all exon-specific BDNF mRNAs in the dentate gyrus of the adult rat hippocampus.
Gene_expression (decreased) of SIS in hippocampus associated with stress, convulsion, ischemia, hippocampus and coma
3) Confidence 0.20 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.86 Pain Relevance 0.16
The levels of acetylated histone H3 at promoters I, IV, and VI were significantly reduced immediately following 2-h SIS, but the reductions were no statistically significant 24 h after the start of the 2-h SIS session (Figure 3A).
Gene_expression (reduced) of SIS associated with stress
4) Confidence 0.20 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.94 Pain Relevance 0.08
FISH study of the tumor with novel probes demonstrated PDGFB rearrangement in most cells (Figure 2).
Gene_expression (rearrangement) of PDGFB associated with cancer
5) Confidence 0.14 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721290 Disease Relevance 0.87 Pain Relevance 0
This molecular event causes aberrant expression of a functional PDGFB leading to activation of PDGFR.
Gene_expression (expression) of PDGFB
6) Confidence 0.12 Published 2007 Journal Biologics : Targets & Therapy Section Abstract Doc Link PMC2721290 Disease Relevance 0.50 Pain Relevance 0
SIS is mainly composed of collagen (90% of dry weight) and contains cytokines and growth factors such as FGF and TGF-?
Gene_expression (composed) of SIS associated with cytokine
7) Confidence 0.03 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2879239 Disease Relevance 0 Pain Relevance 0.05
SIS is mainly composed of collagen (90% of dry weight) and contains cytokines and growth factors such as FGF and TGF-?
Gene_expression (contains) of SIS associated with cytokine
8) Confidence 0.03 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2879239 Disease Relevance 0 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox