INT277701

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.49
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdgfb) cytoplasm (Pdgfb)
Anatomy Link Frequency
hippocampus 1
Pdgfb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 20 92.76 High High
ischemia 1 78.56 Quite High
imagery 2 22.16 Low Low
long-term potentiation 3 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
amygdala 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 64 100.00 Very High Very High Very High
Ring Chromosomes 20 99.02 Very High Very High Very High
Disease 34 91.04 High High
Cancer 58 89.60 High High
Coma 1 79.48 Quite High
Superior Vena Cava Syndrome 2 78.64 Quite High
Cv Unclassified Under Development 1 78.56 Quite High
Convulsion 4 78.16 Quite High
Gastrointestinal Stromal Tumor 8 75.36 Quite High
Metastasis 26 75.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the finding that SIS significantly decreased acetylated H3 at the promoters of exon I and IV of the BDNF gene indicates that epigenetic mechanisms play a role in the stress-induced changes in distinct BDNF transcripts in the hippocampus.
Localization (decreased) of SIS in hippocampus associated with stress and hippocampus
1) Confidence 0.23 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.92 Pain Relevance 0.22
The karyotype showed two ring chromosomes but there was no involvement of 22q13 where the PDGFB gene is located.
Localization (located) of PDGFB gene associated with ring chromosomes
2) Confidence 0.18 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721290 Disease Relevance 0.34 Pain Relevance 0
In approximately 8% of DFSP the COL1A1-PDGFB fusion is not found suggesting that other genes may be involved in these cases, or that there is a cryptic rearrangement of COL1A1 or PDGFB.
Localization (rearrangement) of PDGFB
3) Confidence 0.15 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721290 Disease Relevance 0.23 Pain Relevance 0

General Comments

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