INT277727

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.42
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp7) peptidase activity (Casp7) aging (Casp7)
cytoplasm (Casp7)
Casp7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 96 98.84 Very High Very High Very High
Inflammation 1 45.88 Quite Low
Potency 1 29.04 Quite Low
anesthesia 9 13.68 Low Low
Central nervous system 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
anticonvulsant 3 5.00 Very Low Very Low Very Low
monoamine 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 33 98.84 Very High Very High Very High
Apoptosis 106 97.92 Very High Very High Very High
Retina Disease 51 93.28 High High
Ocular Hypertension 24 91.04 High High
Disease 7 87.32 High High
Cancer 6 84.76 Quite High
Hypoxia 4 79.76 Quite High
Neurodegenerative Disease 3 69.52 Quite High
Death 23 67.84 Quite High
Stress 14 61.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the early recovering phase, caspase-3 did not change (1.147±0.077) and caspase-7 was downregulated (0.646±0.052).
Negative_regulation (downregulated) of caspase-7
1) Confidence 0.21 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.56 Pain Relevance 0.12
We also showed that caspase mRNA was specifically modulated by ischemia, as we reported a time-related increase in caspase-3 and decrease in caspase-7.
Negative_regulation (decrease) of caspase-7 associated with ischemia
2) Confidence 0.21 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.78 Pain Relevance 0.15
At 24 h post I/R, caspase-7 was further reduced (0.536±0.025, p<0.005) while caspase-3 was upregulated (1.656±0.141, p<0.05) (Figure 6A-D).
Negative_regulation (reduced) of caspase-7
3) Confidence 0.19 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.56 Pain Relevance 0.12
The simple isatin analogue, 5-nitroisatin effectively inhibited caspase-7 (Ki 0.29 ?
Negative_regulation (inhibited) of caspase-7
4) Confidence 0.02 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721300 Disease Relevance 0.53 Pain Relevance 0

General Comments

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