INT277757

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 4.14
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Pmf1) chromosome segregation (Pmf1) chromosome (Pmf1)
nucleus (Pmf1) cell cycle (Pmf1) cell division (Pmf1)
Pmf1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 5 84.44 Quite High
palliative 7 64.28 Quite High
Pain 4 51.44 Quite High
corticosteroid 4 40.44 Quite Low
aspirin 8 5.00 Very Low Very Low Very Low
cva 8 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Antihistamine 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
pruritus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myelofibrosis 86 100.00 Very High Very High Very High
Chronic Myelomonocytic Leukemia 30 99.92 Very High Very High Very High
Myelodysplastic Syndromes 158 99.88 Very High Very High Very High
Myeloid Leukemia 65 99.18 Very High Very High Very High
Myeloproliferative Disorder 109 99.16 Very High Very High Very High
Disease 30 86.56 High High
Disease Progression 11 83.20 Quite High
Leukemia 15 69.92 Quite High
Hepatomegaly 2 61.04 Quite High
Splenomegaly 11 60.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
JAK2V617F is present in only about half of PMF and post-ET MF patients, but in the vast majority of post-PV MF patients (Tefferi et al 2005).
Gene_expression (present) of PMF associated with myelodysplastic syndromes and myelofibrosis
1) Confidence 0.12 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721304 Disease Relevance 0.74 Pain Relevance 0.04
Although interferon had some positive data in this group, CML was not very different than our current options for PMF, CMML or other advanced MPDs.
Gene_expression (options) of PMF associated with myeloproliferative disorder, chronic myelomonocytic leukemia, myeloid leukemia and myelofibrosis
2) Confidence 0.12 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721304 Disease Relevance 1.68 Pain Relevance 0.17
PV, ET, and PMF make up the non-leukemic MPN.
Gene_expression (make) of PMF associated with myeloproliferative disorder, myelodysplastic syndromes and myelofibrosis
3) Confidence 0.03 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 1.71 Pain Relevance 0.03

General Comments

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