INT277761

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2007
Negated 5
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 9.23
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (DPM1) endoplasmic reticulum (DPM1)
DPM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 88.72 High High
palliative 18 64.28 Quite High
fibrosis 12 55.56 Quite High
Pain 12 51.44 Quite High
corticosteroid 12 40.44 Quite Low
aspirin 24 5.00 Very Low Very Low Very Low
cva 24 5.00 Very Low Very Low Very Low
Antihistamine 6 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
pruritus 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloproliferative Disorder 192 100.00 Very High Very High Very High
Myelofibrosis 168 100.00 Very High Very High Very High
Chronic Myelomonocytic Leukemia 90 100.00 Very High Very High Very High
Myeloid Leukemia 120 99.72 Very High Very High Very High
Myelodysplastic Syndromes 360 98.64 Very High Very High Very High
Hypereosinophilic Syndrome 84 92.72 High High
Leukemia 36 91.52 High High
Systemic Mastocytosis 72 90.12 High High
Disease 72 86.56 High High
Disease Progression 30 83.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Empiric use of imatinib mesylate against the spectrum of BCR-ABL negative MPDs has had mixed results.
Neg (negative) Gene_expression (negative) of MPDs associated with myeloproliferative disorder
1) Confidence 0.03 Published 2007 Journal Biologics : Targets & Therapy Section Abstract Doc Link PMC2721304 Disease Relevance 2.24 Pain Relevance 0
The BCR-ABL negative MPDs (MPDs; when CML is included it will be stipulated specifically).
Neg (negative) Gene_expression (negative) of MPDs associated with myeloproliferative disorder and myeloid leukemia
2) Confidence 0.03 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721304 Disease Relevance 1.68 Pain Relevance 0.03
Although interferon had some positive data in this group, CML was not very different than our current options for PMF, CMML or other advanced MPDs.
Gene_expression (options) of MPDs associated with myeloproliferative disorder, chronic myelomonocytic leukemia, myeloid leukemia and myelofibrosis
3) Confidence 0.03 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721304 Disease Relevance 1.69 Pain Relevance 0.17
The chronic BCR-ABL negative myeloproliferative disorders (MPDs)
Neg (negative) Gene_expression (negative) of MPDs associated with myeloproliferative disorder
4) Confidence 0.03 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721304 Disease Relevance 1.22 Pain Relevance 0
The discovery of the activating point mutation in the auto-inhibitory pseudokinase domain of JAK2 (the JAK2V617F) was a watershed moment in the understanding of the pathogenesis of the BCR-ABL negative MPDs (Baxter et al 2005; James et al 2005; Kralovics et al 2005; Levine et al 2005).
Neg (negative) Gene_expression (negative) of MPDs associated with myeloproliferative disorder
5) Confidence 0.03 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721304 Disease Relevance 0.72 Pain Relevance 0.04
The BCR-ABL negative MPDs (MPDs; when CML is included it will be stipulated specifically).
Neg (negative) Gene_expression (negative) of MPDs associated with myeloproliferative disorder and myeloid leukemia
6) Confidence 0.03 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721304 Disease Relevance 1.67 Pain Relevance 0.03

General Comments

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