INT277788

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.05
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgal)
Anatomy Link Frequency
T-cells 4
neurons 2
apoptotic cells 2
Itgal (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 11 92.68 High High
Inflammation 53 89.44 High High
cytokine 46 84.64 Quite High
psoriasis 88 82.72 Quite High
Spinal cord 2 73.28 Quite High
ischemia 35 72.68 Quite High
cINOD 7 26.16 Quite Low
Bioavailability 2 24.00 Low Low
rheumatoid arthritis 6 20.00 Low Low
Multiple sclerosis 18 18.88 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 48 99.06 Very High Very High Very High
Adhesions 30 96.12 Very High Very High Very High
Central Nervous System Disease 6 92.68 High High
INFLAMMATION 88 89.44 High High
Multiple Sclerosis 50 89.24 High High
Death 23 83.52 Quite High
Psoriasis 100 82.72 Quite High
Hyperplasia 2 81.32 Quite High
Disease 22 77.32 Quite High
Cv Unclassified Under Development 20 72.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Within 24 hours, treatment with efalizumab reduced the level of CD11a expression on T-cells to 25% of pretreatment levels.
Negative_regulation (reduced) of Gene_expression (expression) of CD11a in T-cells
1) Confidence 0.29 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721316 Disease Relevance 0.07 Pain Relevance 0
In addition to reduced CD11a expression on the surface of CD3+ T-cells, binding of efalizumab also causes a reduced expression of other adhesion molecules, such as CD11b, L-selectin or ?
Negative_regulation (reduced) of Gene_expression (expression) of CD11a in T-cells associated with adhesions
2) Confidence 0.29 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721316 Disease Relevance 0.60 Pain Relevance 0.14
Surprisingly, defective expression of LFA-1 eliminates the capacity of microglial cells to migrate toward injured neurons [131].
Negative_regulation (defective) of Gene_expression (expression) of LFA-1 in neurons
3) Confidence 0.16 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.48 Pain Relevance 0.08
While the percentage of apoptotic cells was again unaltered, surface expression levels of LFA-1 and CD44 were reduced on Th cells from CpdA treated mice in a dose-dependent manner (Fig. 6B).
Negative_regulation (reduced) of Gene_expression (levels) of LFA-1 in apoptotic cells associated with apoptosis
4) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.90 Pain Relevance 0.17

General Comments

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