INT277802

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.59
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rit1) plasma membrane (Rit1) GTPase activity (Rit1)
Anatomy Link Frequency
vasculature 1
vessels 1
LS174T 1
Rit1 (Mus musculus)
Pain Link Frequency Relevance Heat
positron emission tomography 45 96.24 Very High Very High Very High
imagery 117 79.36 Quite High
Potency 3 63.64 Quite High
corticosteroid 4 56.48 Quite High
chemokine 3 35.00 Quite Low
cytokine 4 34.36 Quite Low
Inflammatory marker 2 9.40 Low Low
fibrosis 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 367 100.00 Very High Very High Very High
Acute Myeloid Leukemia 13 98.36 Very High Very High Very High
Myelodysplastic Syndromes 17 98.20 Very High Very High Very High
Follicular Lymphoma 38 98.04 Very High Very High Very High
Colon Cancer 9 97.88 Very High Very High Very High
Glioblastoma 3 97.10 Very High Very High Very High
Coronary Artery Disease 93 94.72 High High
Mantle-cell Lymphoma 19 92.32 High High
Lymphatic System Cancer 123 88.64 High High
Prostate Cancer 3 84.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notwithstanding, it is clear that RIT can produce significant responses in patients with relapsed follicular lymphoma including those patients refractory to rituximab.
Gene_expression (produce) of RIT associated with follicular lymphoma
1) Confidence 0.35 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721318 Disease Relevance 0.61 Pain Relevance 0
RIT study to target and irradiate the tumor vasculature (survival and tumor regression)
Gene_expression (regression) of RIT in vasculature associated with cancer
2) Confidence 0.33 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962274 Disease Relevance 1.38 Pain Relevance 0
We have also examined 225Ac-E4G10 in vascular-targeting strategies to treat animal models of glioblastoma mutiforme25,26 and the colon carcinoma (LS174T) model of tumor vasculature.60 Others have also used vascular-targeting, alpha particle-emitting RIT approaches to treat animal models of disease61–64 or vascular/tumor epitope-targeting RII approaches to PET image tumor.65–67
Gene_expression (approaches) of RIT in LS174T associated with cancer, glioblastoma, colon cancer and positron emission tomography
3) Confidence 0.33 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962274 Disease Relevance 0.87 Pain Relevance 0.15
RIT targeted to the tumor vessels improved median survival and tumor regression
Gene_expression (regression) of RIT in vessels associated with cancer
4) Confidence 0.33 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962274 Disease Relevance 0.99 Pain Relevance 0.04
HD-RIT provided both safer and more effective therapy than C-HDT in this nonrandomized retrospective review.39
Gene_expression (provided) of HD-RIT
5) Confidence 0.22 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886324 Disease Relevance 0.74 Pain Relevance 0.03

General Comments

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