INT277821

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.89
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INCENP) chromosome segregation (INCENP) chromosome (INCENP)
cytoskeleton (INCENP) nucleus (INCENP) protein complex (INCENP)
INCENP (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 8 85.44 High High
headache 2 79.48 Quite High
abatacept 3 33.72 Quite Low
peripheral neuropathy 1 22.28 Low Low
depression 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Headache 2 79.48 Quite High
Convulsion 3 79.08 Quite High
Endocrine Disease 1 77.72 Quite High
Intellectual Impairment 9 70.04 Quite High
Epilepsy 7 69.24 Quite High
Tremor 1 61.16 Quite High
Myoclonus 1 60.84 Quite High
Cognitive Disorder 4 59.60 Quite High
Neuropathic Pain 3 58.52 Quite High
Dysarthria 2 57.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vivo suppression also requires B7 expression on effector cells.
Positive_regulation (requires) of Negative_regulation (suppression) of In vivo
1) Confidence 0.03 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0 Pain Relevance 0.04
Both POLG1 mutations, p.R722H and p.W748S, are situated in the linker region which mediates interaction between the polymerase and exonuclease domains, so that mutations might lead to a significant reduction in the enzyme activity in vitro [31].
Spec (might) Positive_regulation (lead) of Negative_regulation (reduction) of in vitro
2) Confidence 0.01 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2873323 Disease Relevance 0.89 Pain Relevance 0.08

General Comments

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