INT277835

Context Info Confidence 0.03 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.36 Pain Relevance 0.08

extracellular space (EPO, VEGFA) extracellular region (EPO, VEGFA) signal transduction (EPO) growth (VEGFA) aging (EPO) proteinaceous extracellular matrix (VEGFA)

Anatomy Link Frequency glomerulus 2 EPO (Homo sapiens) VEGFA (Homo sapiens)

Pain Link Frequency Relevance Heat headache 2 84.72 cva 1 41.92 dexamethasone 1 38.80 Central nervous system 2 5.00 Inflammation 2 5.00 palliative 1 5.00

Disease Link Frequency Relevance Heat Cancer 22 99.14 Hemoptysis 1 96.72 Metastasis 8 90.64 Membranoproliferative Glomerulonephritis 1 88.24 Headache 2 84.72 Vomiting 5 82.72 Proteinuria 4 77.36 Disorder Of Lipid Metabolism 1 75.92 Hypertension 10 71.20 Hemorrhage 3 62.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

It is possible that low erythropoietin levels in cancer patients may worsen the situation because erythropoietin stimulates VEGF release in the glomerulus (Alvarez et al 1998).

erythropoietin Positive_regulation (stimulates) of Localization (release) of VEGF in glomerulus associated with cancer

1) Confidence 0.03 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721345 Disease Relevance 1.36 Pain Relevance 0.08

General Comments

This test has worked.