INT277845

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.92
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TXK) nucleus (TXK) DNA binding (TXK)
cytoplasm (TXK)
TXK (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 2 84.72 Quite High
methotrexate 2 83.52 Quite High
palliative 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 20 92.24 High High
Cancer 38 91.44 High High
Metastasis 12 82.88 Quite High
Immunotherapy Of Cancer 1 68.80 Quite High
Lung Cancer 4 67.48 Quite High
Disease 23 66.80 Quite High
Advanced Or Metastatic Breast Cancer 15 57.60 Quite High
Head & Neck Cancer 2 50.00 Quite Low
Recurrence 2 32.36 Quite Low
Disease Progression 4 25.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EGF-R and HER-2 combined targeted tyrosine-kinase inhibitors
Negative_regulation (inhibitors) of Gene_expression (combined) of tyrosine-kinase
1) Confidence 0.04 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2868849 Disease Relevance 0.20 Pain Relevance 0.08
Lapatinib, an orally active small molecule, inhibits the tyrosine kinase activity of both epidermal growth factor receptor (EGFR) and HER-2.
Negative_regulation (inhibits) of Gene_expression (activity) of tyrosine kinase
2) Confidence 0.03 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721345 Disease Relevance 0.72 Pain Relevance 0.08

General Comments

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