INT27785

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Context Info
Confidence 0.44
First Reported 1989
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 11
Total Number 14
Disease Relevance 8.00
Pain Relevance 8.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (HTR2A) aging (HTR2A) plasma membrane (HTR2A)
response to stress (HTR2A) cytoplasm (HTR2A) signal transducer activity (HTR2A)
Anatomy Link Frequency
nerve 3
blood vessels 1
pituitary 1
HTR2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 71 100.00 Very High Very High Very High
fluoxetine 42 100.00 Very High Very High Very High
antagonist 22 100.00 Very High Very High Very High
Sciatica 2 100.00 Very High Very High Very High
Catecholamine 2 99.98 Very High Very High Very High
dopamine receptor 2 99.84 Very High Very High Very High
depression 122 99.76 Very High Very High Very High
agonist 21 99.24 Very High Very High Very High
medulla 4 98.96 Very High Very High Very High
sSRI 34 97.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 138 99.76 Very High Very High Very High
Weight Gain 4 99.16 Very High Very High Very High
Heart Rate Under Development 7 98.78 Very High Very High Very High
Sleep Disorders 20 98.52 Very High Very High Very High
Neuroblastoma 6 98.04 Very High Very High Very High
Headache 22 97.72 Very High Very High Very High
Increased Venous Pressure Under Development 17 96.60 Very High Very High Very High
Headache Disorders 1 95.76 Very High Very High Very High
Anxiety Disorder 114 95.56 Very High Very High Very High
Obsessive-compulsive Disorder 9 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tachycardia in the dog and rabbit is due to a release of catecholamines effected via the 5-HT2 receptors on the adrenal medulla and the 5-HT3 receptors on postganglionic cardiac sympathetic nerve fibres, respectively.
Regulation (effected) of 5-HT2 in nerve associated with medulla, heart rate under development and catecholamine
1) Confidence 0.44 Published 1989 Journal Fundam Clin Pharmacol Section Abstract Doc Link 2670724 Disease Relevance 1.12 Pain Relevance 0.10
Trazodone also has 5HT2A and 5HT2C receptor antagonist effects.
Regulation (effects) of 5HT2A associated with antagonist
2) Confidence 0.44 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785860 Disease Relevance 0.77 Pain Relevance 0.44
In vitro pharmacology experiments showed that the 5-hydroxytryptamine (5-HT) type 1B and 1D receptor agonists, eletriptan, naratriptan, rizatriptan, sumatriptan, and zolmitriptan, induced vasoconstriction in the thoracic blood vessels from 38% to 57% of the patients. 5-carboxamidotryptamine (5-CT) and sumatriptan elicited a vasoconstriction that was antagonized by the 5-HT1B receptor antagonist SB224289, whereas the 5-HT1D receptor antagonist BRL115572 had no effect. 5-HT induced a contraction that was inhibited by the 5-HT2A receptor antagonist ketanserin. 5-HT2A, 5-HT1B, and 5-HT1D receptor mRNA levels were detected by real-time PCR in all blood vessels studied.
Regulation (detected) of 5-HT2A in blood vessels associated with sumatriptan, antagonist, agonist and increased venous pressure under development
3) Confidence 0.44 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15821444 Disease Relevance 0.42 Pain Relevance 0.90
Moreover, most of the atypical antipsychotics have a large action spectrum, beyond the only dopamine receptors: their effects on the serotonin receptors--particularly the 5-HT2A and 5-HT2C receptors--suggest that their association to SSRI could be a promising treatment for depression.
Regulation (effects) of 5-HT2A associated with depression, dopamine receptor, ssri and serotonin
4) Confidence 0.44 Published 2004 Journal Encephale Section Abstract Doc Link 15738862 Disease Relevance 0.74 Pain Relevance 0.90
Effects of 5-HT2A receptor antagonist on blood flow in chronically compressed nerve roots.
Regulation (Effects) of 5-HT2A in nerve associated with antagonist and sciatica
5) Confidence 0.44 Published 2004 Journal J. Peripher. Nerv. Syst. Section Title Doc Link 15574139 Disease Relevance 0.37 Pain Relevance 0.75
This study assessed the effects of the 5-HT2A receptor antagonist on nerve vasculature in chronically compressed nerve roots.
Regulation (effects) of 5-HT2A in nerve associated with antagonist
6) Confidence 0.44 Published 2004 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 15574139 Disease Relevance 0.36 Pain Relevance 0.61
The effects of 5-HT1 and 5-HT2 receptor antagonists on these responses were also studied.
Regulation (effects) of 5-HT2 associated with antagonist
7) Confidence 0.44 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10374714 Disease Relevance 0.14 Pain Relevance 0.16
The current study aimed to investigate the possible modulatory role of mI versus fluoxetine or imipramine pretreatments on serotonin-2A receptor (5HT2A-R) and muscarinic acetylcholine receptor (mAChR) function and binding in in vitro systems.
Spec (possible) Regulation (role) of 5HT2A-R associated with serotonin and fluoxetine
8) Confidence 0.43 Published 2004 Journal Metab Brain Dis Section Abstract Doc Link 15214506 Disease Relevance 0.36 Pain Relevance 0.45
Effects of myo-inositol versus fluoxetine and imipramine pretreatments on serotonin 5HT2A and muscarinic acetylcholine receptors in human neuroblastoma cells.
Regulation (Effects) of 5HT2A associated with neuroblastoma, serotonin and fluoxetine
9) Confidence 0.43 Published 2004 Journal Metab Brain Dis Section Title Doc Link 15214506 Disease Relevance 0.33 Pain Relevance 0.42
The current study aimed to investigate the possible modulatory role of mI versus fluoxetine or imipramine pretreatments on serotonin-2A receptor (5HT2A-R) and muscarinic acetylcholine receptor (mAChR) function and binding in in vitro systems.
Spec (possible) Regulation (role) of serotonin-2A receptor associated with serotonin and fluoxetine
10) Confidence 0.43 Published 2004 Journal Metab Brain Dis Section Abstract Doc Link 15214506 Disease Relevance 0.35 Pain Relevance 0.45
On this basis, drugs acting on 5-HT receptors, in particular on 5-HT2 and 5-HT3, are being used or investigated for the clinical management of FM [10,11].
Spec (investigated) Regulation (acting) of 5-HT2
11) Confidence 0.26 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779383 Disease Relevance 0.75 Pain Relevance 0.56
Up-regulation of 5-HT2 serotonin receptor: a possible mechanism of transformed migraine.
Regulation (regulation) of 5-HT2 associated with migraine and serotonin
12) Confidence 0.26 Published 1994 Journal Headache Section Title Doc Link 8132444 Disease Relevance 0.57 Pain Relevance 0.79
Although many genes have been implicated in major depression, the genes regulating serotonergic function such as the serotonin-transporter-linked promoter region 5HTTPR or the serotonin 2A (5-HT2A) are consistently identified.[1618] Other genes involved in regulating neurotrophic factors which affect cellular resilience and neuroplasticity may have an additive role in the determination of developing these illnesses.[19] Catechol-O-methyl transferase (COMT) and monoamine oxidase (MAO) gene polymorphisms perhaps affect the response to other forms of psychological stress by altering the reaction of the hypothalamic-pituitary axis.[20] Genes which have also been shown as indicators for pain states include the 5HTTPR, 5HT2A and COMT polymorphisms.[2122] These shared genetic polymorphisms may represent areas of vulnerability for both depression and pain syndromes.[15]
Regulation (regulating) of 5-HT2A in pituitary associated with stress, pain, depression, syndrome, serotonin and monoamine
13) Confidence 0.26 Published 2010 Journal Indian Journal of Psychiatry Section Body Doc Link PMC2927881 Disease Relevance 1.38 Pain Relevance 1.15
In contrast, MK-212, which demonstrates an affinity for 5HT1A and 5HT2C receptor subtypes, and the 5HT1A receptor agonists ipsapirone or buspirone, have no effect on OC symptom intensity.
Regulation (affinity) of 5HT2C receptor associated with agonist
14) Confidence 0.01 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.34 Pain Relevance 0.50

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