INT277859

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.23
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdk2) cytoplasm (Cdk2) cytosol (Cdk2)
mitosis (Cdk2) nucleus (Cdk2) cytoskeleton (Cdk2)
Cdk2 (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Advanced Or Metastatic Breast Cancer 14 71.20 Quite High
Disease 28 55.36 Quite High
Metastasis 5 54.08 Quite High
Breast Cancer 30 50.04 Quite High
Cancer 22 22.08 Low Low
Disease Progression 6 7.28 Low Low
Recurrence 13 5.00 Very Low Very Low Very Low
Heart Rate Under Development 5 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 4 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other important mechanisms of action comprise the internalization and degradation of Her2 receptor protein (Cuello et al 2001), decrease of cyclin dependent kinase 2 (CDK2) activity via p27 induction (Lane et al 2001), blockade of downstream Her2 signaling pathways (Yakes et al 2002), and inhibition of DNA repair (Nahta et al 2006).
Protein_catabolism (degradation) of CDK2
1) Confidence 0.43 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721347 Disease Relevance 0.23 Pain Relevance 0

General Comments

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