INT277878

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.80
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lysosome (Ids)
Anatomy Link Frequency
brain 1
Ids (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 75 91.48 High High
Spinal cord 6 24.40 Low Low
Antihistamine 12 5.00 Very Low Very Low Very Low
corticosteroid 9 5.00 Very Low Very Low Very Low
Thalamus 9 5.00 Very Low Very Low Very Low
intrathecal 6 5.00 Very Low Very Low Very Low
Neurobehavioral 4 5.00 Very Low Very Low Very Low
carpal tunnel syndrome 3 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mucopolysaccharidoses 21 99.32 Very High Very High Very High
Fabry Disease 4 98.24 Very High Very High Very High
Gauchers Disease 7 97.64 Very High Very High Very High
Disease 89 94.72 High High
Lipidosis 2 72.44 Quite High
Rare Diseases 6 58.76 Quite High
Intellectual Impairment 7 41.32 Quite Low
Pathologic Constriction 3 33.12 Quite Low
Lysosomal Storage Diseases 19 32.08 Quite Low
Multiple Sulfatase Deficiency Disease 3 29.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Its exact function is unclear; however, pathogenic structural rearrangements between IDS2 and IDS have been identified in individuals with MPS II.
IDS2 Binding (rearrangements) of
1) Confidence 0.34 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721351 Disease Relevance 0.06 Pain Relevance 0
Recombinant iduronate-2-sulfatase (idursulfase, Elaprase®; Shire HGT Pharmaceuticals, Cambridge, MA, USA) was approved in July, 2006 in the US and January, 2007 in Europe as a safe and effective treatment for individuals with MPS II.
iduronate-2-sulfatase Binding (Recombinant) of
2) Confidence 0.34 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721351 Disease Relevance 0.43 Pain Relevance 0.08
Its exact function is unclear; however, pathogenic structural rearrangements between IDS2 and IDS have been identified in individuals with MPS II.
IDS Binding (rearrangements) of
3) Confidence 0.34 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721351 Disease Relevance 0.06 Pain Relevance 0
Our data clearly show that the IDS plasma clearance is very slow, which might well be the reason why we can find the IDS in the brain even with low infused doses.
IDS Binding (find) of in brain
4) Confidence 0.33 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2989894 Disease Relevance 0.25 Pain Relevance 0.16

General Comments

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