INT277899

Context Info Confidence 0.02 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.82 Pain Relevance 0

cell differentiation (RASGRP1) Golgi apparatus (RASGRP1) endoplasmic reticulum (RASGRP1) cytoplasm (RASGRP1) cytosol (RASGRP1) lipid binding (RASGRP1)

RASGRP1 (Homo sapiens)

Pain Link Frequency Relevance Heat cva 4 5.00 addiction 1 5.00 pruritus 1 5.00 Angina 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 1 79.04 Colon Cancer 29 76.00 Metastasis 4 74.72 Disease 8 73.32 Cancer 17 68.48 Malignant Neoplastic Disease 1 55.36 Lung Cancer 1 11.28 Toxicity 8 5.00 Hypersensitivity 5 5.00 Exanthema 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

An intracellular signal transduction cascade is initiated with the subsequent phosphorylation of Ras, and other downstream signaling pathways, including the mitogen-activated protein kinase (MAPK) and phosphatidylinositol- 3-kinase (PI3K)/AKT cascades.

Phosphorylation (phosphorylation) of Ras

1) Confidence 0.02 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721355 Disease Relevance 0.82 Pain Relevance 0

General Comments

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