INT277909

Context Info Confidence 0.41 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.17 Pain Relevance 0

endoplasmic reticulum (PIGA) biosynthetic process (PIGA)

PIGA (Homo sapiens)

Pain Link Frequency Relevance Heat cva 17 5.00 cytokine 3 5.00 Pain 3 5.00 abdominal pain 2 5.00 withdrawal 1 5.00 Inflammation 1 5.00 Inflammatory response 1 5.00 Bioavailability 1 5.00 addiction 1 5.00 Inflammatory mediators 1 5.00

Disease Link Frequency Relevance Heat Disease 25 99.16 Paroxysmal Nocturnal Hemoglobinuria 158 92.80 Hematological Disease 14 86.24 Syndrome 3 79.80 Congenital Anomalies 5 69.72 Hyperhomocysteinemia 1 60.88 Thrombosis 24 54.00 Hemolysis 55 40.00 Thrombophilia 5 36.68 Thromboembolism 1 22.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In fact, a series of observations suggest that the PIG-A mutation is necessary but not sufficient per se to cause the disease:

Neg (not) Negative_regulation (sufficient) of Gene_expression (mutation) of PIG-A associated with disease

1) Confidence 0.41 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721357 Disease Relevance 1.17 Pain Relevance 0

General Comments

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