INT277914

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.01
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD59) plasma membrane (CD59)
CD59 (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 1 85.56 High High
rheumatoid arthritis 1 85.12 High High
Inflammatory mediators 1 70.24 Quite High
cva 17 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemolysis 55 99.14 Very High Very High Very High
Paroxysmal Nocturnal Hemoglobinuria 158 96.88 Very High Very High Very High
Disease 25 91.12 High High
Membranous Glomerulonephritis 1 89.12 High High
Dermatomyositis 1 87.44 High High
Systemic Lupus Erythematosus 1 86.76 High High
Psoriasis 1 85.56 High High
Rheumatoid Arthritis 1 85.12 High High
INFLAMMATION 3 69.84 Quite High
Thrombosis 24 27.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, the lack of CD59 on red cell membranes accounts for uncontrolled C5b-9 (MAC) assembly, finally resulting in intravascular hemolysis (Figure 3); theoretically, eculizumab may compensate for the absence of CD59 blocking the MAC formation, thus rendering irrelevant the absence of CD59 on PNH RBCs (Figure 6).
Spec (may) Positive_regulation (compensate) of Negative_regulation (absence) of CD59 associated with paroxysmal nocturnal hemoglobinuria and hemolysis
1) Confidence 0.11 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721357 Disease Relevance 1.01 Pain Relevance 0.12

General Comments

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