INT277914

Context Info Confidence 0.11 First Reported 2008 Last Reported 2008 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.01 Pain Relevance 0.12

extracellular region (CD59) plasma membrane (CD59)

CD59 (Homo sapiens)

Pain Link Frequency Relevance Heat psoriasis 1 85.56 rheumatoid arthritis 1 85.12 Inflammatory mediators 1 70.24 cva 17 5.00 cytokine 3 5.00 Pain 3 5.00 abdominal pain 2 5.00 withdrawal 1 5.00 Inflammation 1 5.00 Inflammatory response 1 5.00

Disease Link Frequency Relevance Heat Hemolysis 55 99.14 Paroxysmal Nocturnal Hemoglobinuria 158 96.88 Disease 25 91.12 Membranous Glomerulonephritis 1 89.12 Dermatomyositis 1 87.44 Systemic Lupus Erythematosus 1 86.76 Psoriasis 1 85.56 Rheumatoid Arthritis 1 85.12 INFLAMMATION 3 69.84 Thrombosis 24 27.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In fact, the lack of CD59 on red cell membranes accounts for uncontrolled C5b-9 (MAC) assembly, finally resulting in intravascular hemolysis (Figure 3); theoretically, eculizumab may compensate for the absence of CD59 blocking the MAC formation, thus rendering irrelevant the absence of CD59 on PNH RBCs (Figure 6).

Spec (may) Positive_regulation (compensate) of Negative_regulation (absence) of CD59 associated with paroxysmal nocturnal hemoglobinuria and hemolysis

1) Confidence 0.11 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721357 Disease Relevance 1.01 Pain Relevance 0.12

General Comments

This test has worked.