INT277920

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.11
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (MADCAM1) aging (MADCAM1) cell adhesion (MADCAM1)
plasma membrane (MADCAM1) embryo development (MADCAM1)
Anatomy Link Frequency
leukocyte 1
MADCAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spastic colon 84 98.72 Very High Very High Very High
Central nervous system 13 94.08 High High
chemokine 5 93.12 High High
Inflammation 99 80.60 Quite High
cytokine 22 72.16 Quite High
Multiple sclerosis 21 57.68 Quite High
Inflammatory response 4 47.44 Quite Low
nud 30 5.00 Very Low Very Low Very Low
corticosteroid 11 5.00 Very Low Very Low Very Low
methotrexate 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 39 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

83 98.72 Very High Very High Very High
Inflammatory Bowel Disease 105 91.12 High High
INFLAMMATION 89 80.60 Quite High
Disease 202 59.72 Quite High
Demyelinating Disease 22 57.68 Quite High
Functional Bowel Disorder 3 50.00 Quite Low
Diarrhoea 10 39.04 Quite Low
Colitis 17 38.08 Quite Low
Autoimmune Disease 3 33.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
7 to bind to their respective endothelial counter-receptors, vascular-cell adhesion molecule-1 (VCAM-1), and mucosal addressin-cell adhesion molecule-1 (MAdCAM-1).
MAdCAM-1 Binding (bind) of associated with adhesions
1) Confidence 0.14 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721358 Disease Relevance 0.52 Pain Relevance 0.08
7 to bind to their respective endothelial counter-receptors, vascular-cell adhesion molecule-1 (VCAM-1), and mucosal addressin-cell adhesion molecule-1 (MAdCAM-1).
addressin-cell adhesion molecule-1 Binding (bind) of associated with adhesions
2) Confidence 0.14 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721358 Disease Relevance 0.52 Pain Relevance 0.08
7 which mediates homing to intestinal mucosa by binding to its endothelial expressed ligand MAdCAM-1.
MAdCAM-1 Binding (binding) of
3) Confidence 0.10 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2879823 Disease Relevance 0.53 Pain Relevance 0.58
This, in turn, causes rolling of the leukocyte along the endothelial surface and activation of integrin expression on the leukocyte surface.85 The integrins then bind tightly to cellular adhesion molecules such as VCAM, ICAM, and MAdCAM86 on the endothelial surface.
MAdCAM86 Binding (bind) of in leukocyte associated with adhesions
4) Confidence 0.00 Published 2007 Journal J Gastroenterol Section Body Doc Link PMC2780674 Disease Relevance 1.06 Pain Relevance 0.23

General Comments

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