INT277935

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.12
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SMAD4) intracellular (SMAD4) protein binding transcription factor activity (SMAD4)
DNA binding (SMAD4) cytoplasm (SMAD4) cytosol (SMAD4)
Anatomy Link Frequency
nucleus 2
SMAD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
long-term potentiation 7 74.80 Quite High
nMDA receptor 2 68.52 Quite High
COX-2 inhibitor 13 37.76 Quite Low
cINOD 7 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
COX2 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 26 94.68 High High
Apoptosis 25 85.76 High High
Autism 148 79.52 Quite High
Stress 9 75.48 Quite High
Hypoxia 1 75.20 Quite High
Liver Cancer 4 70.28 Quite High
Cancer 12 61.08 Quite High
Toxicity 4 39.88 Quite Low
Death 12 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It phosphorylates smad2/3, which consequently binds with smad4 to form an antitumorigenesis transcription factor.
smad4 Binding (binds) of
1) Confidence 0.28 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2944280 Disease Relevance 0 Pain Relevance 0.17
QPCR demonstrated specific upregulation in coxP cells of WIF1, a physiological inhibitor of the pathway (Taniguchi et al 2005), of SMAD4, which counteracts WNT signaling (Gregorieff and Clevers 2005), of TLE1 (groucho), a repressor of ?
SMAD4 Binding (counteracts) of
2) Confidence 0.25 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721360 Disease Relevance 0.31 Pain Relevance 0
Targeted knockdown of SMAD 4, the protein which translocates phosphorylated SMAD members to the nucleus mediating the transcriptional downstream biological actions of TGF?
SMAD 4 Binding (knockdown) of in nucleus
3) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
SMADs dimerize with SMAD4 and translocate to the nucleus where the complex modulates transcription of target genes.
SMAD4 Binding (dimerize) of in nucleus
4) Confidence 0.11 Published 2009 Journal Neurotox Res Section Body Doc Link PMC3006666 Disease Relevance 0.81 Pain Relevance 0

General Comments

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