INT27798

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Context Info
Confidence 0.78
First Reported 1985
Last Reported 2011
Negated 3
Speculated 9
Reported most in Abstract
Documents 111
Total Number 122
Disease Relevance 56.08
Pain Relevance 42.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ntrk2) endosome (Ntrk2) aging (Ntrk2)
plasma membrane (Ntrk2)
Anatomy Link Frequency
neurons 16
brain 5
nerve 5
trigeminal ganglion 4
RVM 4
Ntrk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 503 100.00 Very High Very High Very High
bDMF 476 100.00 Very High Very High Very High
Nerve growth factor 326 100.00 Very High Very High Very High
dorsal root ganglion 242 100.00 Very High Very High Very High
Neuropeptide 210 100.00 Very High Very High Very High
cytokine 100 100.00 Very High Very High Very High
trk B 92 100.00 Very High Very High Very High
qutenza 41 100.00 Very High Very High Very High
Calcitonin gene-related peptide 41 100.00 Very High Very High Very High
agonist 36 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 578 100.00 Very High Very High Very High
Adhesions 53 100.00 Very High Very High Very High
Hyperalgesia 14 99.96 Very High Very High Very High
Injury 1100 99.88 Very High Very High Very High
Infarction 5 99.78 Very High Very High Very High
Contusions 71 99.74 Very High Very High Very High
Neuroleptic Malignant Syndrome 81 99.68 Very High Very High Very High
Parkinson's Disease 3 99.66 Very High Very High Very High
Ulcers 63 99.64 Very High Very High Very High
Tooth Injuries 12 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, our data suggest that decreases in TrkB receptor protein at the site of BDNF infusions in the adult brain represent receptor turnover, but this is not associated with altered expression of trkB mRNA or attenuation of the pharmacological effects of BDNF.
Gene_expression (expression) of trkB mRNA in adult brain
1) Confidence 0.78 Published 1997 Journal Exp. Neurol. Section Abstract Doc Link 9184109 Disease Relevance 0.14 Pain Relevance 0.17
In addition, we sought to further characterize the subpopulation of the afferents expressing TrkB receptors.
Gene_expression (expressing) of TrkB
2) Confidence 0.78 Published 2003 Journal J Endod Section Abstract Doc Link 12597715 Disease Relevance 0.65 Pain Relevance 0.17
The current results also show that an acute injection of cocaine results in a decrease in the number of tyrosine kinase B and C receptors immunoreactive neuronal profiles in specific regions of the nucleus accumbens and neostriatum, indicating that cocaine-induced increases in extracellular dopamine in the striatal complex result in compensatory decreases in the expression of tyrosine kinase B and C receptors.
Gene_expression (expression) of tyrosine kinase B in nucleus accumbens associated with nucleus accumbens, dopamine and cocaine
3) Confidence 0.77 Published 2003 Journal Neuroscience Section Abstract Doc Link 12605901 Disease Relevance 0 Pain Relevance 0.72
Single- and double-label immunohistochemistry were used to determine the extent to which the tyrosine kinase B and C receptors, are expressed in enkephalin-immunopositive or enkephalin-immunonegative neuronal profiles in the rat neostriatum and nucleus accumbens.
Gene_expression (expressed) of tyrosine kinase B in nucleus accumbens associated with nucleus accumbens and enkephalin
4) Confidence 0.77 Published 2003 Journal Neuroscience Section Abstract Doc Link 12605901 Disease Relevance 0 Pain Relevance 0.83
One or 14 days following the last of seven daily injections of 15 mg/kg cocaine or saline there were no differences in the numbers of tyrosine kinase B or C receptors immunoreactive neuronal profiles between these treatment groups.Collectively, the present results indicate that tyrosine kinase B and C receptors in the neostriatum and nucleus accumbens are co-localized in enkephalin-positive and enkephalin-negative neuronal profiles, which suggests that the striatal medium spiny neurons expressing tyrosine kinase B and C receptors include those that project to the pallidum or the ventral mesencephalon.
Gene_expression (expressing) of tyrosine kinase B in nucleus accumbens associated with nucleus accumbens, enkephalin and cocaine
5) Confidence 0.77 Published 2003 Journal Neuroscience Section Abstract Doc Link 12605901 Disease Relevance 0 Pain Relevance 1.04
By the use of two different trkB antibodies we observed that 7.7% and 10.8% of DRG neurons co-expressed BDNF + trkB but not trkA, respectively, in rat and mouse.
Neg (not) Gene_expression (expressed) of trkB in DRG associated with dorsal root ganglion
6) Confidence 0.77 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262634 Disease Relevance 0.46 Pain Relevance 0.58
Expression of BDNF and TrkB following NMS and CRD stimulation was determined using immunohistochemistry.
Spec (determined) Gene_expression (Expression) of TrkB associated with neuroleptic malignant syndrome
7) Confidence 0.76 Published 2009 Journal Neurosignals Section Abstract Doc Link 19546592 Disease Relevance 1.08 Pain Relevance 0.62
These data demonstrate that NMS increases BDNF and TrkB expression in the descending pain systems, which may contribute to the development of NMS-induced visceral hyperalgesia.
Gene_expression (expression) of TrkB in visceral associated with pain, neuroleptic malignant syndrome and nud
8) Confidence 0.76 Published 2009 Journal Neurosignals Section Abstract Doc Link 19546592 Disease Relevance 1.24 Pain Relevance 0.66
The results revealed an increase in the expression of BDNF and TrkB in the amygdala after NMS.
Gene_expression (expression) of TrkB in amygdala associated with neuroleptic malignant syndrome and amygdala
9) Confidence 0.76 Published 2009 Journal Neurosignals Section Abstract Doc Link 19546592 Disease Relevance 1.06 Pain Relevance 0.66
Furthermore, a significant interactive effect of NMS and CRD on the colocalization coefficient of TrkB and phospho-extracellular signal-regulated kinase expression in both the amygdala and RVM were found.
Gene_expression (expression) of TrkB in RVM associated with neuroleptic malignant syndrome, amygdala and rostral ventromedial medulla
10) Confidence 0.76 Published 2009 Journal Neurosignals Section Abstract Doc Link 19546592 Disease Relevance 0.97 Pain Relevance 0.68
An interactive effect of NMS and CRD on the expression of TrkB, but not BDNF, was found in the RVM.
Gene_expression (expression) of TrkB in RVM associated with neuroleptic malignant syndrome and rostral ventromedial medulla
11) Confidence 0.76 Published 2009 Journal Neurosignals Section Abstract Doc Link 19546592 Disease Relevance 1.04 Pain Relevance 0.67
Neonatal maternal separation increases brain-derived neurotrophic factor and tyrosine kinase receptor B expression in the descending pain modulatory system.
Gene_expression (expression) of tyrosine kinase receptor B in brain associated with pain and nociceptor
12) Confidence 0.76 Published 2009 Journal Neurosignals Section Title Doc Link 19546592 Disease Relevance 1.03 Pain Relevance 0.79
Because the spinothalamic tract (STT) is a well-characterized pathway for its role in the transfer and integration of sensory and nociceptive informations, this study in rats aimed to 1) determine whether neurons of the STT pathway express the TrkB receptor, 2) establish the rostrocaudal and laminar distribution of STT-TrkB neurons in the whole spinal cord, and 3) test the potential functionality of TrkB expression in these cells by investigating the ability of BDNF to activate the MAP kinase ERK.
Gene_expression (express) of TrkB in neurons associated with nociception, spinothalamic tract and spinal cord
13) Confidence 0.76 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 15977164 Disease Relevance 0.33 Pain Relevance 0.70
TrkB expression and phospho-ERK activation by brain-derived neurotrophic factor in rat spinothalamic tract neurons.
Gene_expression (expression) of TrkB in neurons associated with qutenza and spinothalamic tract neurons
14) Confidence 0.76 Published 2005 Journal J. Comp. Neurol. Section Title Doc Link 15977164 Disease Relevance 0.31 Pain Relevance 0.54
Because the spinothalamic tract (STT) is a well-characterized pathway for its role in the transfer and integration of sensory and nociceptive informations, this study in rats aimed to 1) determine whether neurons of the STT pathway express the TrkB receptor, 2) establish the rostrocaudal and laminar distribution of STT-TrkB neurons in the whole spinal cord, and 3) test the potential functionality of TrkB expression in these cells by investigating the ability of BDNF to activate the MAP kinase ERK.
Gene_expression (expression) of TrkB in neurons associated with nociception, spinothalamic tract and spinal cord
15) Confidence 0.76 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 15977164 Disease Relevance 0.30 Pain Relevance 0.77
This study provides for the first time evidence of an entorhinal cortex influenced concentration-dependent relationship between the release of endogenous glutamate in vivo and neuronal expression of mRNAs for BDNF and its receptor trkB in the hippocampus.
Gene_expression (expression) of trkB in neuronal associated with glutamate and hippocampus
16) Confidence 0.74 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9013789 Disease Relevance 0 Pain Relevance 0.65
Synthesis of the neurotrophic factor brain-derived neurotrophic factor (BDNF) and its receptor TrkB in the hippocampus have been proposed to be influenced by endogenous glutamate.
Gene_expression (Synthesis) of TrkB in hippocampus associated with glutamate and hippocampus
17) Confidence 0.74 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9013789 Disease Relevance 0 Pain Relevance 0.34
The influence of chronic electroconvulsive seizure (ECS) or antidepressant drug treatments on expression of brain-derived neurotrophic factor (BDNF) and its receptor, trkB, was examined by in situ hybridization and Northern blot.
Spec (examined) Gene_expression (expression) of trkB in brain associated with antidepressant and convulsion
18) Confidence 0.74 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472505 Disease Relevance 0.81 Pain Relevance 0.15
Klintsova et al. (13) have reported that both complex motor learning and moderately paced running exercises affected the expression of BDNF in the motor cortex and cerebellum, although the expression of TrkB differed with training conditions.
Gene_expression (expression) of TrkB in cerebellum
19) Confidence 0.70 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967002 Disease Relevance 0.31 Pain Relevance 0.07
BACKGROUND CONTEXT: Brain-derived neurotrophic factor (BDNF) and its cognate receptor, the tyrosine kinase B (TrkB), are normally expressed in neurons and implicated in multiple pathological conditions.
Gene_expression (expressed) of TrkB in neurons
20) Confidence 0.70 Published 2010 Journal Spine J Section Abstract Doc Link 20452292 Disease Relevance 0.15 Pain Relevance 0.32

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