INT277989

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.66
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CDH5) plasma membrane (CDH5)
Anatomy Link Frequency
endothelial cells 1
CDH5 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 6 85.68 High High
cytokine 12 80.60 Quite High
Inflammation 22 41.92 Quite Low
agonist 2 32.24 Quite Low
aspirin 10 31.36 Quite Low
ischemia 16 5.00 Very Low Very Low Very Low
Central nervous system 9 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Inflammatory marker 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 42 99.20 Very High Very High Very High
Adhesions 25 98.54 Very High Very High Very High
Diabetes Mellitus 12 89.20 High High
Atherosclerosis 70 74.88 Quite High
Aging 2 71.92 Quite High
Metastasis 76 70.64 Quite High
Cancer 88 68.76 Quite High
INFLAMMATION 31 53.16 Quite High
Cardiovascular Disease 14 50.00 Quite Low
Hypoxia 1 44.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also showed that VEGF secreted from breast cancer cells significantly increased the adhesion and penetration of breast cancer cells across the HBMECs monolayer, via changes of VE-cadherin which were inhibited by SU-1498 inhibitor for VEGFR-2 and calcium chelator.
Positive_regulation (changes) of VE-cadherin associated with breast cancer and adhesions
1) Confidence 0.11 Published 2011 Journal Pathology Research International Section Body Doc Link PMC3021881 Disease Relevance 1.23 Pain Relevance 0.08
Early EPCs circulate in blood, home to the denuded endothelium, differentiate to endothelial cells (a process where they acquire CD144+ and vVW+) and thus repopulate the endothelium or secrete local paracrine factor to increase the physiological state of resident cells (Ingram et al 2005; Bardoff and Dimmeler 2006).
Positive_regulation (acquire) of CD144 in endothelial cells
2) Confidence 0.10 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721378 Disease Relevance 0.11 Pain Relevance 0.07
Nevertheless, statin-mediated biphasic effect seems to be associated to a late increase of CD34+/CD144+ EPCs, which show a potential effect of statins on EPC differentiation from early to advanced progenitors (Deschaseaux et al 2007).
Positive_regulation (increase) of CD144
3) Confidence 0.09 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721378 Disease Relevance 0.32 Pain Relevance 0

General Comments

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