INT277994

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 6.21
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Trap1) protein folding (Trap1) mitochondrion (Trap1)
response to stress (Trap1)
Trap1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 19 94.28 High High
tolerance 2 94.00 High High
metalloproteinase 10 92.04 High High
rheumatoid arthritis 6 86.44 High High
cytokine 58 84.88 Quite High
Inflammation 68 84.48 Quite High
Infliximab 52 50.00 Quite Low
Glutamate 12 44.68 Quite Low
Hippocampus 1 40.48 Quite Low
ischemia 35 18.56 Low Low
Disease Link Frequency Relevance Heat
Cancer 57 100.00 Very High Very High Very High
Necrosis 16 100.00 Very High Very High Very High
Shock 3 100.00 Very High Very High Very High
Death 59 99.96 Very High Very High Very High
Apoptosis 100 99.92 Very High Very High Very High
Stress 57 99.56 Very High Very High Very High
INFLAMMATION 95 93.92 High High
Disease 328 86.76 High High
Targeted Disruption 28 86.44 High High
Rheumatoid Arthritis 6 86.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, Deas et al. review that PINK1 protects cells against oxidative stress induced apoptosis by interacting with the mitochondrial chaperone tumor necrosis factor receptor-associated protein 1 (TRAP1)/heat shock protein 75 (Hsp75) (Pridgeon et al., 2007).
TRAP1 Binding (interacting) of associated with stress, necrosis, cancer, shock and apoptosis
1) Confidence 0.26 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.83 Pain Relevance 0
Moreover, Deas et al. review that PINK1 protects cells against oxidative stress induced apoptosis by interacting with the mitochondrial chaperone tumor necrosis factor receptor-associated protein 1 (TRAP1)/heat shock protein 75 (Hsp75) (Pridgeon et al., 2007).
Hsp75 Binding (interacting) of associated with stress, necrosis, cancer, shock and apoptosis
2) Confidence 0.26 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.83 Pain Relevance 0
Moreover, Deas et al. review that PINK1 protects cells against oxidative stress induced apoptosis by interacting with the mitochondrial chaperone tumor necrosis factor receptor-associated protein 1 (TRAP1)/heat shock protein 75 (Hsp75) (Pridgeon et al., 2007).
tumor necrosis factor receptor-associated protein 1 Binding (interacting) of associated with stress, necrosis, cancer, shock and apoptosis
3) Confidence 0.26 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.83 Pain Relevance 0
These activated kinases recruit tumor necrosis factor receptor-associated factor (TRAF) 6, which is an E3 ubiquitin ligase required for activation of NF?
tumor necrosis factor receptor-associated factor Binding (recruit) of associated with necrosis and cancer
4) Confidence 0.08 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.37 Pain Relevance 0.09
aggregates into trimolecular complexes, which bind and activate the TNF receptors, TNF receptor type 1(TNFR1) and TNF receptor type 2 (TNFR2).
TNF receptor type 1 Binding (bind) of
5) Confidence 0.06 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721383 Disease Relevance 1.57 Pain Relevance 0.22
can induce apoptosis via recruiting TNFR-associated death domain protein (TRADD), FADD, and Caspase-8, and then modulate Caspase-9 and Caspase-3.
TNFR-associated Binding (recruiting) of associated with apoptosis and death
6) Confidence 0.03 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2907730 Disease Relevance 1.17 Pain Relevance 0.05
(which binds to TNF receptor 1) would cause primarily detrimental effects whereas membrane bound TNF-?
TNF receptor 1 Binding (binds) of
7) Confidence 0.03 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.60 Pain Relevance 0.17

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