INT278006

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.07
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Sstr3) plasma membrane (Sstr3) cytoplasm (Sstr3)
signal transducer activity (Sstr3)
Anatomy Link Frequency
superior 1
Sstr3 (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 64 94.24 High High
dexamethasone 2 93.92 High High
agonist 17 91.40 High High
Dopamine 9 53.00 Quite High
tolerance 8 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 3 99.92 Very High Very High Very High
Adenoma 18 93.04 High High
Acth-secreting Pituitary Adenoma 7 92.40 High High
Cancer 41 92.32 High High
Acromegaly 40 91.56 High High
Pituitary Acth Hypersecretion 3 50.00 Quite Low
Coronary Heart Disease 6 46.76 Quite Low
Nelson Syndrome 3 44.24 Quite Low
Pituitary Cancer 9 41.80 Quite Low
Myocardial Infarction 1 38.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apoptosis is associated with SSTR3 and possibly also with SSTR2 signaling (Danilla et al 2001; Bevan 2005).
SSTR3 Binding (associated) of associated with apoptosis
1) Confidence 0.33 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.70 Pain Relevance 0.09
In fact, octreotide (that binds preferentially sst2 but only modestly sst5), but not pasireotide (a universal ligand with high binding affinity for sst1, sst2, sst3, and sst5), lost most of its ACTH-inhibiting potential with glucocorticoid pretreatment53 or in patients with CD in vivo.54 Two studies55,56 investigated the effects of SS analogs in human corticotroph adenoma tissues; a superior ACTH inhibition by pasireotide as compared with octreotide55 and a dissociation in some adenomas between the antisecretory and antiproliferative effects of pasireotide56 were reported similar to what is observed in acromegaly.57,58

Efficacy in clinical studies

sst3 Neg (not) Binding (ligand) of in superior associated with adenoma, acromegaly, acth-secreting pituitary adenoma and somatostatin
2) Confidence 0.08 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963160 Disease Relevance 0.37 Pain Relevance 0.62

General Comments

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