INT278021

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.50
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (RUNX1T1) embryo development (BMP2) protein complex (BMP2)
cell-cell signaling (BMP2) cytoplasm (BMP2) generation of precursor metabolites and energy (RUNX1T1)
BMP2 (Homo sapiens)
RUNX1T1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 1 46.64 Quite Low
Pain 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 7 95.76 Very High Very High Very High
Injury 18 80.84 Quite High
Closed Fractures 2 76.88 Quite High
Fracture Healing 32 70.24 Quite High
Hypercalcemia 1 38.84 Quite Low
Tibial Fractures 12 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 6 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings correlate with in vitro studies that demonstrate that rhBMP-2 upregulates expression of both Cbfa-1 and OSX (Wozney and Rosen 1998; Kawaguchi et al 2001; Kolbeck et al 2003).
rhBMP-2 Positive_regulation (upregulates) of Gene_expression (expression) of Cbfa-1
1) Confidence 0.02 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 0.50 Pain Relevance 0

General Comments

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