INT278036

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.64
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BMP2) growth (BMP2) extracellular region (BMP2)
embryo development (BMP2) protein complex (BMP2) cell-cell signaling (BMP2)
Anatomy Link Frequency
skin 1
BMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
bDMF 12 99.96 Very High Very High Very High
Pain 3 49.48 Quite Low
Nerve growth factor 6 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
fifth nerve 1 5.00 Very Low Very Low Very Low
neurotrophin 3 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 19 93.68 High High
Tibial Fractures 12 86.48 High High
Infection 6 59.44 Quite High
Pain 3 49.48 Quite Low
Wound Healing 3 29.96 Quite Low
Fracture Healing 32 6.64 Low Low
Osteoporosis 7 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 6 5.00 Very Low Very Low Very Low
Adhesions 5 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A comparison between gene expression in velvet and skin samples from pedicle and frontal showed an opposite trend, with most genes, including BDNF, BMP2, FGF2, L1-CAM, Meteorin and NR-CAM, appearing downregulated in velvet.
Negative_regulation (downregulated) of BMP2 in skin associated with bdmf
1) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0.09
Since many surgeons were unaware of this smaller study which showed that the rate of secondary intervention was reduced with the addition of rhBMP-2 to reamed or unreamed IM nailing, Swiontkowski et al (2006) reported a subgroup analysis of the combined results of these two studies.
Negative_regulation (reduced) of rhBMP-2
2) Confidence 0.32 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 0.64 Pain Relevance 0

General Comments

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