INT27805

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Context Info
Confidence 0.60
First Reported 1989
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.11
Pain Relevance 5.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Avpr1a) response to stress (Avpr1a) signal transducer activity (Avpr1a)
Anatomy Link Frequency
plasma 1
Avpr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central grey 20 100.00 Very High Very High Very High
antagonist 17 100.00 Very High Very High Very High
opiate 4 100.00 Very High Very High Very High
Analgesic 3 99.98 Very High Very High Very High
antinociception 6 99.96 Very High Very High Very High
narcan 4 99.68 Very High Very High Very High
nociceptor 4 99.68 Very High Very High Very High
mu opioid receptor 1 98.44 Very High Very High Very High
Enkephalin 6 98.24 Very High Very High Very High
agonist 15 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 20 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 1 98.52 Very High Very High Very High
Pain 12 94.12 High High
Nociception 2 90.92 High High
Heart Rate Under Development 2 89.40 High High
Injury 4 82.72 Quite High
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional evidence for the regulation of cytosolic Ca2+ activity via V1A-receptors and beta-adrenoceptors in rat CCD.
Regulation (regulation) of V1A
1) Confidence 0.60 Published 1997 Journal Cell Calcium Section Title Doc Link 9132299 Disease Relevance 0 Pain Relevance 0.43
[Effects of ohmefentanyl at anesthetic dose on plasma levels of corticosterone, cortisol and antidiuretic hormone in rats].
Regulation (Effects) of antidiuretic hormone in plasma associated with analgesic
2) Confidence 0.15 Published 1997 Journal Yao Xue Xue Bao Section Title Doc Link 11327028 Disease Relevance 0.24 Pain Relevance 0.27
The vasopressin V1 antagonist, [d(CH2)5Tyr(Me)]-AVP (20 micrograms/kg), indomethacin (5 mg/kg), or verapamil (150 micrograms/kg) did not affect any of these cardiovascular responses.
Neg (not) Regulation (affect) of vasopressin V1 associated with antagonist
3) Confidence 0.12 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2675635 Disease Relevance 0.26 Pain Relevance 0.23
Considering the present results we propose a V1A-receptor and beta-adrenoceptor dependent modulation of [Ca2+]i in rat CCD.
Regulation (modulation) of V1A-receptor
4) Confidence 0.11 Published 1997 Journal Cell Calcium Section Abstract Doc Link 9132299 Disease Relevance 0 Pain Relevance 0.44
Through V2, not V1 receptor relating to endogenous opiate peptides, arginine vasopressin in periaqueductal gray regulates antinociception in the rat.
Regulation (regulates) of V1 receptor associated with antinociception, analgesic, opiate and central grey
5) Confidence 0.03 Published 2006 Journal Regul. Pept. Section Title Doc Link 17011056 Disease Relevance 1.30 Pain Relevance 2.05
The data suggest that AVP in the PAG, through V2 rather than V1 receptor, regulates antinociception, which progress relates to enkephalin and endorphin.
Regulation (regulates) of V1 receptor associated with antinociception, enkephalin and central grey
6) Confidence 0.03 Published 2006 Journal Regul. Pept. Section Abstract Doc Link 17011056 Disease Relevance 1.30 Pain Relevance 1.77

General Comments

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