| A study by Athanasoupolos et al. demonstrated that tolterodine could safely be taken in combination with an alpha blocker in patients with urodynamically proven BOO, without the development of AUR. Reynard et al. have demonstrated that anticholinergic use in BPH patients leads to a small increase in the post-void residual (PVR) without significantly increasing the risk of AUR. Both these agents can be safely combined in the management of BPH, especially in patients with predominantly irritative symptoms and low PVR.