INT2781

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Context Info
Confidence 0.28
First Reported 1979
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 0.83
Pain Relevance 3.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc3a1) plasma membrane (Slc3a1) carbohydrate metabolic process (Slc3a1)
Anatomy Link Frequency
striatum 5
whiskers 2
nucleus accumbens 1
Slc3a1 (Rattus norvegicus)
Slc3a1 - A2M (1)
Pain Link Frequency Relevance Heat
Enkephalin 13 100.00 Very High Very High Very High
Dopamine 13 100.00 Very High Very High Very High
agonist 3 99.68 Very High Very High Very High
Nucleus accumbens 8 99.30 Very High Very High Very High
cocaine 14 98.44 Very High Very High Very High
MU agonist 1 98.28 Very High Very High Very High
Kappa opioid receptor 1 98.12 Very High Very High Very High
Analgesic 2 97.46 Very High Very High Very High
withdrawal 3 96.20 Very High Very High Very High
GABAergic 6 95.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 23 100.00 Very High Very High Very High
Catalepsy 18 75.60 Quite High
Hypokinesia 4 42.48 Quite Low
Peripheral Arterial Disease 20 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 3 5.00 Very Low Very Low Very Low
Parkinson's Disease 1 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The obtained results suggest that in the nucleus accumbens and striatum there is an opposite regulation between PENK and D2 receptor gene expression a short time after single and chronic cocaine administration.
Regulation (regulation) of Gene_expression (expression) of D2 in striatum associated with nucleus accumbens and cocaine
1) Confidence 0.28 Published 1995 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 8998398 Disease Relevance 0 Pain Relevance 0.57
This was true for both arc 1 (D1 and C1) whiskers, and arc 2 (D2 and C2) whiskers.
Regulation (true) of Gene_expression (whiskers) of D2 in whiskers associated with aids-related complex
2) Confidence 0.25 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2525689 Disease Relevance 0.34 Pain Relevance 0
Our study was undertaken in order to analyze in detail the expression of the D1 and D2 receptor genes in the efferent striatal populations, with special reference to the various striatal areas, and to yield insights into the question about D1 and D2 mRNA localization in the striatum.
Spec (analyze) Regulation (analyze) of Spec (analyze) Gene_expression (expression) of D2 in striatum
3) Confidence 0.24 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7636023 Disease Relevance 0 Pain Relevance 0.41
Cotreatment with the kappa opioid agonist U69593 enhances locomotor sensitization to the D2/D3 dopamine agonist quinpirole and alters dopamine D2 receptor and prodynorphin mRNA expression in rats.
Regulation (alters) of Gene_expression (expression) of D2 associated with dopamine, mu agonist, analgesic and agonist
4) Confidence 0.15 Published 2007 Journal Psychopharmacology (Berl.) Section Title Doc Link 17619861 Disease Relevance 0 Pain Relevance 0.73
The obtained results suggest that in the nucleus accumbens and striatum there is an opposite regulation between PENK and D2 receptor gene expression a short time after single and chronic cocaine administration.
Regulation (regulation) of in nucleus accumbens Gene_expression (expression) of D2 in striatum associated with nucleus accumbens and cocaine
5) Confidence 0.09 Published 1995 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 8998398 Disease Relevance 0 Pain Relevance 0.57
These two direct and indirect pathways are differentially regulated by dopamine through their respective expression of the excitatory D1 and inhibitory D2 receptors.
Regulation (regulated) of Gene_expression (expression) of D2 associated with dopamine
6) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704377 Disease Relevance 0.08 Pain Relevance 0.43
Mean distances between centers of VPM cross-sections around the D2 column vary between 403 and 517 ?
Regulation (sections) of Gene_expression (column) of D2
7) Confidence 0.04 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2936807 Disease Relevance 0.42 Pain Relevance 0
Systemic administration of Met-enkephalin, (D-Ala2)-Met-enkephalin, beta-endorphin, and (D-Ala2)-beta-endorphin: effects on eating, drinking and activity measures in rats.
Regulation (effects) of Gene_expression (administration) of D-Ala2 (A2M) associated with enkephalin
8) Confidence 0.03 Published 1979 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 523499 Disease Relevance 0 Pain Relevance 0.67

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