INT278117

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.38
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TP63) nucleoplasm (TP63) anatomical structure formation involved in morphogenesis (TP63)
Golgi apparatus (TP63) nucleolus (TP63) nucleus (TP63)
Anatomy Link Frequency
Th1 cells 1
TP63 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 24 99.80 Very High Very High Very High
antagonist 71 88.16 High High
cytokine 24 83.72 Quite High
Inflammation 58 68.00 Quite High
Potency 62 50.16 Quite High
Multiple sclerosis 11 42.48 Quite Low
palliative 2 41.24 Quite Low
Eae 12 33.64 Quite Low
pain flank 1 9.20 Low Low
psoriasis 55 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 25 99.70 Very High Very High Very High
Adhesions 4 99.42 Very High Very High Very High
Gastrointestinal Stromal Tumor 8 98.62 Very High Very High Very High
Leiomyosarcoma 17 98.56 Very High Very High Very High
Skin Cancer 25 98.32 Very High Very High Very High
Candida Infection 2 97.92 Very High Very High Very High
Abscess 1 97.50 Very High Very High Very High
Cancer 119 95.84 Very High Very High Very High
Bacterial Infection 1 93.76 High High
Metastasis 37 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, since GIST resembles LMS histopathologically and only recently can be reliably distinguished from LMS, many GISTs have been diagnosed as LMSs in older series.
Negative_regulation (distinguished) of LMS associated with leiomyosarcoma and gastrointestinal stromal tumor
1) Confidence 0.32 Published 2009 Journal Sarcoma Section Body Doc Link PMC2801456 Disease Relevance 0.96 Pain Relevance 0
We hypothesized that SNAI1 reactivation occurs in oral squamous cell carcinoma (OSCC) where it might also be associated with focal adhesion kinase (FAK) expression and p63 loss.


Negative_regulation (loss) of p63 associated with skin cancer and adhesions
2) Confidence 0.18 Published 2010 Journal BMC Clin Pathol Section Abstract Doc Link PMC2829523 Disease Relevance 1.24 Pain Relevance 0
These patients are prone to chronic Staphylococcus aureus abscesses, chronic candidiasis, and pulmonary infections.53–55 IL-12 and Th1 cells are important in fighting infections as those with defects in p40 or in the IL-12 receptor subunit, IL-12R?
Negative_regulation (defects) of p40 in Th1 cells associated with abscess, infection and candida infection
3) Confidence 0.04 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.18 Pain Relevance 0.17
Compound 36, for example, a hybrid of a preferred LHS for P2X7 and RHS for KATP possesses potent activity at hP2X7 (pIC50?
Negative_regulation (preferred) of RHS associated with potassium channel
4) Confidence 0.03 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0 Pain Relevance 0.48
Compound 36, for example, a hybrid of a preferred LHS for P2X7 and RHS for KATP possesses potent activity at hP2X7 (pIC50?
Negative_regulation (hybrid) of RHS associated with potassium channel
5) Confidence 0.03 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0 Pain Relevance 0.48

General Comments

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