INT27813

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Context Info
Confidence 0.29
First Reported 1989
Last Reported 2008
Negated 3
Speculated 4
Reported most in Body
Documents 12
Total Number 19
Disease Relevance 14.26
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CENPJ) cytoskeleton (CENPJ) cell division (CENPJ)
cytoplasm (CENPJ)
Anatomy Link Frequency
lung 2
nasal 1
phrenic nerve 1
respiratory 1
CENPJ (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 9 100.00 Very High Very High Very High
Neurobehavioral 8 99.84 Very High Very High Very High
depression 258 96.52 Very High Very High Very High
alcohol 36 69.08 Quite High
Inflammation 14 41.04 Quite Low
Inflammatory stimuli 1 36.08 Quite Low
headache 11 28.40 Quite Low
tolerance 7 22.00 Low Low
Serotonin 44 5.00 Very Low Very Low Very Low
antidepressant 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 9 99.94 Very High Very High Very High
Cardiovascular Disease 78 99.88 Very High Very High Very High
Apnoea 846 99.76 Very High Very High Very High
Depression 397 99.36 Very High Very High Very High
Death 30 99.32 Very High Very High Very High
Sleep Disorders 246 98.98 Very High Very High Very High
Hypertension 101 98.88 Very High Very High Very High
Obstructive Sleep Apnea 711 98.80 Very High Very High Very High
Adult Respiratory Distress Syndrome 18 98.28 Very High Very High Very High
Syndrome 34 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
De Miguel and colleagues (2002) evaluated the effects of CPAP therapy on lung function in patients with overlap syndrome over two consecutive years.
Regulation (effects) of CPAP in lung associated with syndrome
1) Confidence 0.29 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650593 Disease Relevance 0.81 Pain Relevance 0.03
Influence of CPAP on reflex responses to tracheal irritation in anesthetized humans.
Regulation (Influence) of CPAP associated with anesthesia
2) Confidence 0.27 Published 1989 Journal J. Appl. Physiol. Section Title Doc Link 2676952 Disease Relevance 0.37 Pain Relevance 0.10
MAS therapy improves subjective sleepiness and improves AHI relative to controls but is less effective than CPAP in reducing AHI.
Regulation (effective) of CPAP associated with sleep disorders
3) Confidence 0.24 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 0.68 Pain Relevance 0
Effect of CPAP on daytime function
Regulation (Effect) of CPAP
4) Confidence 0.24 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 0.50 Pain Relevance 0.04
Effect of CPAP on cardiovascular risk factors
Regulation (Effect) of CPAP
5) Confidence 0.24 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 1.08 Pain Relevance 0
Effect of CPAP on sleep architecture
Regulation (Effect) of CPAP
6) Confidence 0.24 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 0.33 Pain Relevance 0
They concluded that their results support a protective effect of CPAP therapy against death from cardiovascular disease in patients with OSA.
Regulation (effect) of CPAP associated with apnoea, cardiovascular disease and death
7) Confidence 0.08 Published 2006 Journal Respir Res Section Body Doc Link PMC1373626 Disease Relevance 1.41 Pain Relevance 0
In our study, left ventricular diameters and both systolic and diastolic functions of all subjects were in normal limits and did not significantly change after CPAP therapy.
Neg (not) Regulation (change) of CPAP
8) Confidence 0.08 Published 2006 Journal Respir Res Section Body Doc Link PMC1373626 Disease Relevance 1.43 Pain Relevance 0
Following the initial increase in end-expiratory Pabd during methacholine infusion, there was no significant change with IPAP, EPAP, and CPAP.
Neg (no) Regulation (change) of CPAP
9) Confidence 0.08 Published 2004 Journal Crit Care Section Body Doc Link PMC420031 Disease Relevance 0 Pain Relevance 0
Thus, we compared the independent effects of IPAP, EPAP, and CPAP on the inspiratory work of breathing and EELV changes using a canine model of methacholine-induced bronchospasm.
Neg (independent) Regulation (effects) of CPAP associated with bronchospasm
10) Confidence 0.05 Published 2004 Journal Crit Care Section Body Doc Link PMC420031 Disease Relevance 0.28 Pain Relevance 0
We aimed to determine the effects of nasal continuous positive airway pressure (CPAP) therapy on right ventricular myocardial performance index (MPI) in OSA patients without hypertension.


Spec (determine) Regulation (effects) of CPAP in nasal associated with apnoea and hypertension
11) Confidence 0.05 Published 2006 Journal Respir Res Section Abstract Doc Link PMC1373626 Disease Relevance 1.25 Pain Relevance 0
Possible mechanisms responsible for CPAP mediated improvement in lung function in patients with coexistent COPD and OSA includes counteraction of auto-positive end-expiratory pressure, decreasing respiratory muscle load, and respiratory work of breathing (Petrof et al 1990; Mezzanotte et al 1994).
Spec (Possible) Regulation (responsible) of CPAP in lung associated with apnoea and pulmonary disease
12) Confidence 0.05 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629968 Disease Relevance 1.31 Pain Relevance 0
The constancy of the control data also supports the assumption that the effects of 5 min IPAP, EPAP, and CPAP did not persist after the discontinuation of positive airway pressure.


Regulation (effects) of CPAP
13) Confidence 0.05 Published 2004 Journal Crit Care Section Body Doc Link PMC420031 Disease Relevance 0.08 Pain Relevance 0
Whereas the severity of OSA itself does not seem to have a differential impact on mood improvement after CPAP therapy, the severity of depressive symptoms associated with OSA may impact response to CPAP treatment.
Spec (may) Regulation (response) of CPAP associated with apnoea and depression
14) Confidence 0.05 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1181621 Disease Relevance 0.91 Pain Relevance 0.15
However, whereas Borak, Munoz and Henke do not find any effect of CPAP therapy on mood, Yu observed a positive effect on mood of both CPAP therapy and the subtherapeutic CPAP control group.
Regulation (effect) of CPAP
15) Confidence 0.04 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1181621 Disease Relevance 0.91 Pain Relevance 0.20
However, whereas Borak, Munoz and Henke do not find any effect of CPAP therapy on mood, Yu observed a positive effect on mood of both CPAP therapy and the subtherapeutic CPAP control group.
Regulation (effect) of CPAP
16) Confidence 0.04 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1181621 Disease Relevance 0.92 Pain Relevance 0.20
A systematic review on the influence of CPAP on neurobehavioral performance of patients with OSA also supported the clinical perspective that typically depressive symptoms remit together with EDS under CPAP therapy [31].
Regulation (influence) of CPAP associated with apnoea, depression, ehlers-danlos syndrome and neurobehavioral
17) Confidence 0.02 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1181621 Disease Relevance 1.49 Pain Relevance 0.26
APRV = airway pressure release ventilation; ARDS = acute respiratory distress syndrome; ATC = automatic tube compensation; BiPAP = biphasic positive airway pressure; CMV = controlled mechanical ventilation; CPAP = continuous positive airway pressure; CT = computed tomography; DO2 = oxygen delivery; IMV = intermittent mandatory ventilation; PSV = pressure support ventilation; VA/Q = ventilation/perfusion; VT = tidal volume.



Regulation (controlled) of CPAP in respiratory associated with cytomegalovirus infection and adult respiratory distress syndrome
18) Confidence 0.02 Published 2004 Journal Crit Care Section Body Doc Link PMC1065046 Disease Relevance 0.42 Pain Relevance 0
To investigate the regulation of breathing and ventilatory response in surfactant-depleted young cats during PAV and during continuous positive airway pressure (CPAP) early after surfactant instillation in relation to phrenic nerve activity (PNA) and the activity of PSRs.


Spec (investigate) Regulation (regulation) of CPAP in phrenic nerve
19) Confidence 0.02 Published 2006 Journal Respir Res Section Abstract Doc Link PMC1420291 Disease Relevance 0.09 Pain Relevance 0

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