INT278144

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.55
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Jak3) intracellular (Jak3) kinase activity (Jak3)
cytoplasm (Jak3)
Jak3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 21 91.64 High High
Potency 2 58.88 Quite High
cytokine 11 44.68 Quite Low
Arthritis 10 17.36 Low Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
psoriasis 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 20 91.64 High High
Organ Transplantation 4 63.80 Quite High
Autoimmune Disease 12 62.52 Quite High
Hypersensitivity 6 61.64 Quite High
Targeted Disruption 3 54.24 Quite High
Severe Combined Immunodeficiency 2 53.28 Quite High
Pressure And Volume Under Development 5 43.52 Quite Low
Arthritis 10 17.36 Low Low
Disease 5 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the reported and available JAK2 inhibitors have some degree of JAK3 inhibitory activity and therefore the observed effect could, at least partly, be due to concomitant JAK3 inhibition.
Positive_regulation (due) of Negative_regulation (inhibition) of JAK3
1) Confidence 0.23 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.55 Pain Relevance 0.11

General Comments

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