INT278145

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.45
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Chuk) nucleus (Chuk) kinase activity (Chuk)
cytoplasm (Chuk)
Chuk (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 21 98.32 Very High Very High Very High
Inflammation 44 82.72 Quite High
metalloproteinase 3 79.16 Quite High
fibrosis 4 35.92 Quite Low
Arthritis 10 5.00 Very Low Very Low Very Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
psoriasis 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 2 99.08 Very High Very High Very High
Targeted Disruption 16 95.12 Very High Very High Very High
Cancer 44 86.12 High High
INFLAMMATION 43 82.72 Quite High
Apoptosis 12 70.52 Quite High
Hepatocellular Cancer 47 66.00 Quite High
Autoimmune Disease 12 63.60 Quite High
Hepatitis B Virus Infection 8 61.44 Quite High
Hepatitis C Virus Infection 8 60.64 Quite High
Opportunistic Infections 1 47.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, enhanced JNK activation in IKK?
Positive_regulation (enhanced) of Positive_regulation (activation) of IKK
1) Confidence 0.29 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.93 Pain Relevance 0.04
Upon activation of the cell following the binding of cytokines and growth factors or by UV or stress, a signal transduction cascade unravels that leads to the activation of the serine-threonine kinases, IKK1 and IKK2.
Positive_regulation (leads) of Positive_regulation (activation) of IKK1 associated with stress and cytokine
2) Confidence 0.09 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.52 Pain Relevance 0.24

General Comments

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