INT278152

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.24
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.93
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Syk) plasma membrane (Syk) cytoplasm (Syk)
Syk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 5 91.20 High High
Inflammation 105 91.12 High High
dexamethasone 10 89.60 High High
cytokine 55 81.84 Quite High
Arthritis 50 80.28 Quite High
Bioavailability 20 48.68 Quite Low
headache 5 41.36 Quite Low
Potency 10 29.60 Quite Low
chemokine 5 29.04 Quite Low
rheumatoid arthritis 25 15.20 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 100 91.12 High High
Autoimmune Disease 60 90.56 High High
Anaphylaxis 5 84.96 Quite High
Arthritis 50 80.28 Quite High
Organ Transplantation 20 78.08 Quite High
Hypersensitivity 30 77.36 Quite High
Targeted Disruption 15 68.52 Quite High
Severe Combined Immunodeficiency 10 67.56 Quite High
Peritonitis 5 67.48 Quite High
Adhesions 5 57.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BAY 61-3606 has been reported to be an ATP-competitive and selective inhibitor of Syk with IC50?
Negative_regulation (inhibitor) of Syk
1) Confidence 0.24 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.23 Pain Relevance 0.11
A number of JAK3 inhibitors have been disclosed in an abstract, manuscript, or at scientific meetings without disclosing their structure and/or pharmacology profile (for example, R348, an inhibitor of JAK3 and Syk [49]); such inhibitors are not covered in this review.
Negative_regulation (inhibitor) of Syk
2) Confidence 0.24 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.60 Pain Relevance 0.11
Syk inhibitors
Negative_regulation (inhibitors) of Syk
3) Confidence 0.24 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.48 Pain Relevance 0.15
This review describes some of the recent developments in the search for inhibitors of IKK2, Syk, Lck, and JAK3 kinases.
Negative_regulation (inhibitors) of Syk
4) Confidence 0.17 Published 2008 Journal Purinergic Signal Section Abstract Doc Link PMC2721774 Disease Relevance 0.34 Pain Relevance 0.08
Compound 13 has been reported to be a potent and selective Syk inhibitor with IC50?
Negative_regulation (inhibitor) of Syk
5) Confidence 0.17 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.27 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox