INT278162

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.64
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LCK) aging (LCK) Golgi apparatus (LCK)
plasma membrane (LCK) cytoplasm (LCK)
LCK (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 20 92.40 High High
Bioavailability 8 70.88 Quite High
Inflammation 42 50.00 Quite Low
psoriasis 6 44.48 Quite Low
rheumatoid arthritis 10 42.92 Quite Low
cytokine 22 30.68 Quite Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 2 99.68 Very High Very High Very High
Chronic Myeloid Leukemia 2 99.58 Very High Very High Very High
Arthritis 20 92.40 High High
Pressure And Volume Under Development 10 88.84 High High
Experimental Arthritis 2 69.04 Quite High
Disease 10 65.84 Quite High
Cancer 8 55.16 Quite High
INFLAMMATION 40 50.00 Quite Low
Middle Cerebral Artery Infarction 2 48.56 Quite Low
Graft Vs Host Disease 2 45.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compound 16, which is closely related to 15, is a modestly selective inhibitor of Lck with IC50?
Negative_regulation (inhibitor) of Gene_expression (selective) of Lck
1) Confidence 0.15 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0 Pain Relevance 0.04
Compound 23, a close structural analog of dasatinib (BMS-354825), a marketed kinase inhibitor drug for the treatment of chronic myelogenous leukemia (CML), is a potent, selective, and ATP-competitive inhibitor of Lck and other Src family kinases (IC50?
Negative_regulation (inhibitor) of Gene_expression (selective) of Lck associated with myeloid leukemia and chronic myeloid leukemia
2) Confidence 0.15 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.64 Pain Relevance 0.08

General Comments

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