INT27818

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Context Info
Confidence 0.34
First Reported 1989
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.77
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (PADI1) cytoplasm (PADI1)
Anatomy Link Frequency
reticulum 2
sternomastoid 1
PADI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 15 99.72 Very High Very High Very High
Glutamate receptor 4 78.88 Quite High
Inflammatory mediators 4 75.00 Quite High
Multiple sclerosis 2 71.64 Quite High
withdrawal 3 70.00 Quite High
Pain 2 58.68 Quite High
cINOD 1 54.00 Quite High
nMDA receptor 16 40.64 Quite Low
corticosteroid 6 37.28 Quite Low
Parenteral administration 3 27.92 Quite Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 8 99.20 Very High Very High Very High
Paralysis 6 91.00 High High
Sepsis 21 84.80 Quite High
Injury 11 81.52 Quite High
Sleep Disorders 12 78.24 Quite High
INFLAMMATION 5 75.00 Quite High
Disease 21 74.96 Quite High
Death 6 74.64 Quite High
Stroke 2 73.24 Quite High
Demyelinating Disease 2 71.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One such molecule affected is protein disulfide isomerase (PDI), an enzyme responsible for normal protein folding in the endoplasmic reticulum (ER).
Regulation (responsible) of PDI in reticulum
1) Confidence 0.34 Published 2007 Journal Int. Rev. Neurobiol. Section Abstract Doc Link 17678953 Disease Relevance 1.49 Pain Relevance 0.14
One such molecule affected is protein disulfide isomerase (PDI), an enzyme responsible for normal protein folding in the endoplasmic reticulum (ER).
Regulation (affected) of PDI in reticulum
2) Confidence 0.34 Published 2007 Journal Int. Rev. Neurobiol. Section Abstract Doc Link 17678953 Disease Relevance 1.51 Pain Relevance 0.14
The current data cannot discriminate whether the duration of mechanical ventilation itself or the dose of analgesics/sedatives is responsible for the lower TwPdi values, nor whether other cofactors may have interfered.
Spec (whether) Regulation (responsible) of TwPdi associated with analgesic
3) Confidence 0.29 Published 2010 Journal Crit Care Section Body Doc Link PMC2945090 Disease Relevance 0.43 Pain Relevance 0.18
Cocontraction of neck muscles, including the sternomastoid, was present, but its influence in the CMS-induced Pdi seems minimal.
Regulation (influence) of Pdi in sternomastoid
4) Confidence 0.24 Published 1989 Journal J. Appl. Physiol. Section Abstract Doc Link 2676953 Disease Relevance 0.06 Pain Relevance 0.11
Also, droplet sizes and PDI can be controlled very easily by changing only one formulation parameter, SOR.
Regulation (controlled) of PDI
5) Confidence 0.22 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2963933 Disease Relevance 0.11 Pain Relevance 0.05
Although no data for each individual are presented, the averages suggest no major changes in Pdi over a period of about 30 days.
Neg (no) Regulation (changes) of Pdi
6) Confidence 0.18 Published 2010 Journal Crit Care Section Body Doc Link PMC2945090 Disease Relevance 0 Pain Relevance 0
In the remaining seven patients, no TwPdi values are available because of intolerance, technical problems, or active abdominal contraction during the experiment.
Neg (no) Regulation (values) of TwPdi
7) Confidence 0.18 Published 2010 Journal Crit Care Section Body Doc Link PMC2945090 Disease Relevance 0.16 Pain Relevance 0.04
The folding catalysts also include enzymes of the protein-disulfide isomerase (PDI) family, which are responsible for the formation of disulfide bonds [31-33].
Regulation (responsible) of PDI
8) Confidence 0.12 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0 Pain Relevance 0

General Comments

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