INT278195

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Context Info
Confidence 0.46
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.87
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ciita)
Anatomy Link Frequency
T cells 6
Ciita (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 45 85.68 High High
Inflammation 70 81.52 Quite High
Crohn's disease 10 78.08 Quite High
metalloproteinase 5 35.24 Quite Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colitis 185 98.56 Very High Very High Very High
Targeted Disruption 105 94.40 High High
Inflammatory Bowel Disease 30 94.04 High High
Disease 45 90.24 High High
Multiple Sclerosis 10 88.72 High High
Death 15 88.32 High High
INFLAMMATION 65 75.36 Quite High
Granuloma 15 50.56 Quite High
Weight Loss 30 28.08 Quite Low
Body Weight 35 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously we suggested another role of CIITA in Th1/Th2 balance by demonstrating that forced expression of CIITA in murine T cells repressed Th1 immunity both in vitro and in vivo.
Positive_regulation (forced) of Gene_expression (expression) of CIITA in T cells
1) Confidence 0.46 Published 2006 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2721999 Disease Relevance 0.44 Pain Relevance 0.04
Overexpression of CIITA in T Cells Aggravates Th2-Mediated Colitis in Mice

The MHC class II transactivator (CIITA) is the master transcriptional regulator of genes involved in MHC class II restricted antigen presentation.

Positive_regulation (Overexpression) of Gene_expression (Overexpression) of CIITA associated with colitis
2) Confidence 0.46 Published 2006 Journal Journal of Korean Medical Science Section Title Doc Link PMC2721999 Disease Relevance 0.68 Pain Relevance 0.04
In this study, we showed that forced expression of CIITA in T cells enhanced Th2 immunity, which was confirmed by the increased susceptibility of CIITA-Tg mice to oxazolone-induced colitis, a Th2-mediated IBD model.
Positive_regulation (forced) of Gene_expression (expression) of CIITA in T cells associated with colitis and inflammatory bowel disease
3) Confidence 0.46 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.80 Pain Relevance 0.10
All together, it could be suggested that overexpression of CIITA in T cells inhibits Th1 differentiation both in vivo and in vitro.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CIITA in T cells
4) Confidence 0.46 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.90 Pain Relevance 0.12
To clarify the discrepancies between the results obtained from CIITA deficient mouse and CIITA overexpressing mice regarding the role of CIITA function in Th differentiation, immune reaction induced under Th2 condition should be tested in the CIITA transgenic mice.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of CIITA associated with targeted disruption
5) Confidence 0.40 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 1.05 Pain Relevance 0.12

General Comments

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