INT2782

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Context Info
Confidence 0.62
First Reported 1979
Last Reported 2009
Negated 10
Speculated 26
Reported most in Abstract
Documents 75
Total Number 101
Disease Relevance 15.04
Pain Relevance 38.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
arcuate nucleus 22
hypothalamus 14
brain 12
pituitary 12
neurons 8
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 124 100.00 Very High Very High Very High
Opioid 73 100.00 Very High Very High Very High
Pain 51 100.00 Very High Very High Very High
opiate 48 100.00 Very High Very High Very High
Enkephalin 40 100.00 Very High Very High Very High
narcan 39 100.00 Very High Very High Very High
Versed 32 100.00 Very High Very High Very High
Endogenous opioid 30 100.00 Very High Very High Very High
antagonist 25 100.00 Very High Very High Very High
opioid receptor 25 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 56 100.00 Very High Very High Very High
Pain 44 100.00 Very High Very High Very High
Stress 32 100.00 Very High Very High Very High
Diabetes Mellitus 24 100.00 Very High Very High Very High
Obesity 12 100.00 Very High Very High Very High
Shock 7 100.00 Very High Very High Very High
Galactorrhea 5 100.00 Very High Very High Very High
Immunization 1 100.00 Very High Very High Very High
Post Operative Pain 1 99.68 Very High Very High Very High
Neuropathic Pain 4 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using in situ hybridization, we examined whether diurnal changes in POMC gene expression occur in the arcuate nucleus.
Spec (whether) Regulation (changes) of Gene_expression (expression) of POMC gene in arcuate nucleus
1) Confidence 0.62 Published 1990 Journal Mol. Endocrinol. Section Abstract Doc Link 2233745 Disease Relevance 0 Pain Relevance 0.09
Diurnal pattern of proopiomelanocortin gene expression in the arcuate nucleus of proestrous, ovariectomized, and steroid-treated rats: a possible role in cyclic luteinizing hormone secretion.
Spec (possible) Regulation (role) of Gene_expression (expression) of proopiomelanocortin in arcuate nucleus
2) Confidence 0.62 Published 1990 Journal Mol. Endocrinol. Section Title Doc Link 2233745 Disease Relevance 0 Pain Relevance 0.10
Effect of chronic morphine treatment on beta-endorphin biosynthesis by the rat neurointermediate lobe.
Regulation (Effect) of Gene_expression (biosynthesis) of beta-endorphin in lobe associated with morphine
3) Confidence 0.62 Published 1981 Journal Eur. J. Pharmacol. Section Title Doc Link 6268419 Disease Relevance 0.09 Pain Relevance 0.44
The concomitant administration of morphine and naloxone completely prevented the effect of morphine on POMC gene expression indicating that the inhibitory influence of morphine is likely to be mediated by opioid receptors.
Regulation (effect) of Gene_expression (expression) of POMC gene associated with narcan, opioid receptor and morphine
4) Confidence 0.62 Published 1993 Journal Neuropeptides Section Abstract Doc Link 8413862 Disease Relevance 0 Pain Relevance 1.28
In order to investigate the role of opiates in the regulation of POMC gene expression in the rat arcuate nucleus, we studied the effects of chronic administration of the opioid drug morphine and an opiate receptor antagonist naloxone on POMC mRNA levels as measured by in situ hybridization, 4-day treatment with naloxone (4 mg/kg/day) produced a 60% increase in the number of silver grains overlying POMC neurons.
Spec (investigate) Regulation (role) of Gene_expression (expression) of POMC gene in neurons associated with antagonist, narcan, opiate, opioid and morphine
5) Confidence 0.62 Published 1993 Journal Neuropeptides Section Abstract Doc Link 8413862 Disease Relevance 0 Pain Relevance 0.97
The regulation of beta-endorphin expression was first assessed in spinal neuronal culture, then we electrotranfected this plasmid into the spinal cord of mononeuropathic rats and evaluated the analgesic potential of this therapy in vivo by thermal and mechanical withdrawal latency.
Regulation (regulation) of Gene_expression (expression) of beta-endorphin in spinal cord associated with analgesic, withdrawal and spinal cord
6) Confidence 0.62 Published 2004 Journal Gene Ther. Section Abstract Doc Link 15116065 Disease Relevance 0.40 Pain Relevance 0.66
Regional specificity of testosterone regulation of proopiomelanocortin gene expression in the arcuate nucleus of the male rat brain.
Regulation (regulation) of Gene_expression (expression) of proopiomelanocortin gene in arcuate nucleus
7) Confidence 0.62 Published 1989 Journal Endocrinology Section Title Doc Link 2721451 Disease Relevance 0 Pain Relevance 0.10
Based on these observations we conclude that there is a heterogeneous population of POMC neurons in the arcuate nucleus and that testosterone regulates POMC gene expression in a select group of these cells located in the rostral portion of the arcuate nucleus.
Regulation (regulates) of Gene_expression (expression) of POMC gene in arcuate nucleus
8) Confidence 0.62 Published 1989 Journal Endocrinology Section Abstract Doc Link 2721451 Disease Relevance 0 Pain Relevance 0
We therefore examined the effects of opioid receptor agonists, including recently discovered endogenous opioid peptides, on POMC gene expression using the AtT20PL cell line, a subclone of AtT20 in which the rat POMC 5'-promoter-luciferase fusion gene was stably incorporated.
Spec (examined) Regulation (effects) of Gene_expression (expression) of POMC gene in AtT20 associated with endogenous opioid, agonist and opioid receptor
9) Confidence 0.61 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11474216 Disease Relevance 0 Pain Relevance 0.65
Although opioid peptides are involved in the regulation of the hypothalamic-pituitary-adrenal axis, their role in pro-opiomelanocortin (POMC) gene expression at the pituitary level is not known.
Regulation (role) of Gene_expression (expression) of pro-opiomelanocortin in pituitary associated with opioid
10) Confidence 0.61 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11474216 Disease Relevance 0 Pain Relevance 0.57
These findings, that the effects of morphine on HPA activation or POMC mRNA expression depend on the presence of stress, suggest a counter-regulatory role of opiates on a stress response and opioid gene expression.
Regulation (effects) of Gene_expression (expression) of POMC mRNA associated with stress, opiate, opioid and morphine
11) Confidence 0.60 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10556776 Disease Relevance 0.33 Pain Relevance 0.97
Pre- and posttranslational regulation of beta-endorphin biosynthesis in the CNS: effects of chronic naltrexone treatment.
Regulation (regulation) of Gene_expression (biosynthesis) of beta-endorphin
12) Confidence 0.60 Published 1993 Journal J. Neurochem. Section Title Doc Link 8417165 Disease Relevance 0 Pain Relevance 0.38
Opioid regulation of proopiomelanocortin (POMC) gene expression in the rat brain as studied by in situ hybridization.
Regulation (regulation) of Gene_expression (expression) of POMC in brain associated with opioid
13) Confidence 0.60 Published 1993 Journal Neuropeptides Section Title Doc Link 8413862 Disease Relevance 0 Pain Relevance 1.01
Regulation of POMC gene expression has been analyzed in different rat tissues.
Regulation (Regulation) of Gene_expression (expression) of POMC gene
14) Confidence 0.59 Published 1983 Journal Peptides Section Abstract Doc Link 6318201 Disease Relevance 0 Pain Relevance 0.25
[The mechanisms of the GABA-ergic regulation of beta-endorphin levels in the hypothalamic structures of prenatally stressed male rats].
Regulation (regulation) of Gene_expression (levels) of beta-endorphin associated with gaba
15) Confidence 0.58 Published 2000 Journal Fiziol Zh Section Title Doc Link 10867869 Disease Relevance 0.17 Pain Relevance 0.30
The regulation of beta-endorphin expression was first assessed in cultures of dorsal root ganglion neurons.
Regulation (regulation) of Gene_expression (expression) of beta-endorphin in neurons associated with ganglion cysts and root ganglion neuron
16) Confidence 0.57 Published 2008 Journal J Gene Med Section Abstract Doc Link 18064731 Disease Relevance 0.10 Pain Relevance 0.41
Effect of morphine on proopiomelanocortin gene expression and peptide levels in the hypothalamus.
Regulation (Effect) of Gene_expression (expression) of proopiomelanocortin gene in hypothalamus associated with morphine
17) Confidence 0.54 Published 1996 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8883945 Disease Relevance 0 Pain Relevance 0.55
The aim of this study was to examine the effects of delta 9-tetrahydrocannabinol on proopiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus and anterior lobe of the pituitary.
Spec (examine) Regulation (effects) of Gene_expression (expression) of proopiomelanocortin in arcuate nucleus
18) Confidence 0.54 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9128838 Disease Relevance 0 Pain Relevance 0.21
The influence of the diabetic state on beta-endorphin synthesis and concentration in the central nervous system is another factor that might change pain perception in diabetes.
Regulation (influence) of Gene_expression (synthesis) of beta-endorphin in central nervous system associated with pain, diabetes mellitus and central nervous system
19) Confidence 0.50 Published 1988 Journal Diabetes Section Abstract Doc Link 3410166 Disease Relevance 1.23 Pain Relevance 1.76
Opioid regulation of proopiomelanocortin (POMC) gene expression in the rat brain as studied by in situ hybridization.
Regulation (regulation) of Gene_expression (expression) of proopiomelanocortin in brain associated with opioid
20) Confidence 0.45 Published 1993 Journal Neuropeptides Section Title Doc Link 8413862 Disease Relevance 0 Pain Relevance 1.01

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