INT278241

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.16
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (IHH) extracellular space (IHH) extracellular region (IHH)
plasma membrane (IHH) cell-cell signaling (IHH)
IHH (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 9 93.56 High High
cytokine 16 70.64 Quite High
fibrosis 23 52.92 Quite High
chemokine 6 19.72 Low Low
anesthesia 21 5.00 Very Low Very Low Very Low
Inflammation 18 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Hepatitis 27 99.52 Very High Very High Very High
INFLAMMATION 27 93.20 High High
Frailty 6 91.60 High High
Stress 36 88.28 High High
Liver Disease 11 72.44 Quite High
Malignant Neoplastic Disease 6 71.84 Quite High
Viral Infection 3 70.24 Quite High
Cancer 37 69.76 Quite High
Obesity 6 69.48 Quite High
Chronic Hepatitis C 6 64.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Eight genes discriminated perfectly between groups A and B: seven up-regulated genes (PAI1, THBS1, IL8, PTGS2, CXCR4, JUN, and FOS), and one down-regulated gene (IHH).
Regulation (regulated) of IHH
1) Confidence 0.31 Published 2008 Journal Hepatology (Baltimore, Md.) Section Abstract Doc Link PMC2816363 Disease Relevance 0.27 Pain Relevance 0.05
Among the 26 dysregulated genes, we identified eight that perfectly discriminated between group A and group B (AUC-ROC, 1.000), one of which is a down-regulated gene (IHH) that codes one of the three mammalian Hedgehog (Hh) proteins.
Regulation (regulated) of IHH
2) Confidence 0.31 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.62 Pain Relevance 0.06
Eight genes perfectly discriminated between groups A and B (AUC-ROC, 1.000): seven up-regulated genes (PAI1, THBS1, IL8, PTGS2, CXCR4, JUN, and FOS) and one down-regulated gene (IHH).
Regulation (regulated) of IHH
3) Confidence 0.19 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.21 Pain Relevance 0.04
IHH, cells transduced with lentivectors coding for telomerase, were used as a positive control for quality of cell extracts.
Regulation (control) of IHH
4) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.07 Pain Relevance 0

General Comments

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