INT278294

Context Info Confidence 0.01 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.82 Pain Relevance 0.03

nucleoplasm (ESR1) enzyme binding (ESR1) DNA binding (ESR1) protein complex (ESR1) cytoplasm (ESR1) signal transduction (ESR1)

ESR1 (Homo sapiens) SHBG (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 29 50.56 Inflammatory marker 6 16.12 cytokine 2 5.00 Restless leg syndrome 1 5.00 fibrosis 1 5.00 ischemia 1 5.00 Pain 1 5.00 Inflammatory response 1 5.00 alcohol 1 5.00 metalloproteinase 1 5.00

Disease Link Frequency Relevance Heat Obesity 25 92.12 Disorder Of Lipid Metabolism 26 85.20 Nicotine Addiction 9 73.68 Disease 9 67.16 Peripheral Arterial Disease 31 56.96 INFLAMMATION 36 50.56 Cardiovascular Disease 44 50.00 Infection 18 50.00 Aging 8 50.00 Atherosclerosis 19 46.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Contrary to expectations, higher WBC and ESR associate with lower SBP and DBP among Tsimane, and CRP is not significant in the analyses.

ESR Binding (associate) of SBP

1) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722089 Disease Relevance 0.82 Pain Relevance 0.03

General Comments

This test has worked.