INT2783

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 1979
Last Reported 2011
Negated 5
Speculated 4
Reported most in Abstract
Documents 86
Total Number 94
Disease Relevance 8.84
Pain Relevance 45.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc3a1) plasma membrane (Slc3a1) carbohydrate metabolic process (Slc3a1)
Anatomy Link Frequency
striatum 11
whiskers 7
neurons 5
brain 3
ileum 2
Slc3a1 (Rattus norvegicus)
Slc3a1 - A2M (1)
Pain Link Frequency Relevance Heat
Dopamine 1834 100.00 Very High Very High Very High
Enkephalin 475 100.00 Very High Very High Very High
projection neuron 386 100.00 Very High Very High Very High
agonist 339 100.00 Very High Very High Very High
dopamine receptor 258 100.00 Very High Very High Very High
antagonist 185 100.00 Very High Very High Very High
Nucleus accumbens 112 100.00 Very High Very High Very High
Opioid 47 100.00 Very High Very High Very High
opioid receptor 29 100.00 Very High Very High Very High
Dynorphin 28 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 77 99.92 Very High Very High Very High
Sleep Disorders 135 99.72 Very High Very High Very High
Diabetes Mellitus 182 99.64 Very High Very High Very High
Depression 91 99.36 Very High Very High Very High
Targeted Disruption 48 98.44 Very High Very High Very High
Catalepsy 41 97.80 Very High Very High Very High
Increased Venous Pressure Under Development 180 96.04 Very High Very High Very High
Disease 245 95.72 Very High Very High Very High
Neuroblastoma 2 95.00 High High
Glioma 2 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All detectable prodynorphin cells in the core expressed D1 mRNA but not D2 mRNA.
Neg (not) Gene_expression (expressed) of D2 mRNA
1) Confidence 0.65 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 8550882 Disease Relevance 0 Pain Relevance 0.29
In these clusters, proenkephalin-positive cells expressed both prodynorphin and D1 mRNAs, but they did not express D2 mRNA.
Neg (not) Gene_expression (express) of D2 mRNA
2) Confidence 0.65 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 8550882 Disease Relevance 0 Pain Relevance 0.28
Conversely, approximately 95% of the proenkephalin-positive cells in this region expressed D2 mRNA but not D1 mRNA.
Neg (not) Gene_expression (expressed) of D2 mRNA
3) Confidence 0.65 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 8550882 Disease Relevance 0 Pain Relevance 0.28
While ITH CaCl2 was devoid of any effect on the analgesia induced by ITH morphine, it did antagonize the analgesic effect produced by ITH injection of dynorphin A or (D-Pen2,D-Pen5)-enkephalin (DPDPE).
Gene_expression (produced) of D-Pen2 associated with dynorphin, analgesic, enkephalin, morphine, analgesia and intrathecal
4) Confidence 0.55 Published 1989 Journal Int. J. Neurosci. Section Abstract Doc Link 2807764 Disease Relevance 0 Pain Relevance 1.63
N-0923 was therefore the most D2 receptor selective agonist tested.
Gene_expression (selective) of D2 associated with agonist
5) Confidence 0.48 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7903387 Disease Relevance 0 Pain Relevance 0.77
Concentrations of mu sites were assessed with the selective ligand 3H-[D-ala2,mePhe4,gly-ol5]enkephalin (DAGO).
Gene_expression (assessed) of D-ala2 associated with enkephalin
6) Confidence 0.41 Published 1985 Journal J. Neurosci. Section Abstract Doc Link 2983043 Disease Relevance 0 Pain Relevance 0.66
Our study was undertaken in order to analyze in detail the expression of the D1 and D2 receptor genes in the efferent striatal populations, with special reference to the various striatal areas, and to yield insights into the question about D1 and D2 mRNA localization in the striatum.
Spec (analyze) Gene_expression (expression) of D2 in striatum
7) Confidence 0.40 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7636023 Disease Relevance 0 Pain Relevance 0.41
The D1 and D2 genes are the most widely expressed in the caudate-putamen, the accumbens nucleus, and the olfactory tubercle.
Gene_expression (expressed) of D2 in caudate-putamen associated with nucleus accumbens
8) Confidence 0.40 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7636023 Disease Relevance 0 Pain Relevance 0.29
These results confirm that the D1 and D2 receptor genes are expressed in distinct populations of striatal efferent neurons in the normal adult rat.
Gene_expression (expressed) of D2 in efferent neurons
9) Confidence 0.40 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7636023 Disease Relevance 0 Pain Relevance 0.31
D1 and D2 dopamine receptor gene expression in the rat striatum: sensitive cRNA probes demonstrate prominent segregation of D1 and D2 mRNAs in distinct neuronal populations of the dorsal and ventral striatum.
Gene_expression (expression) of D2 in striatum associated with dopamine receptor
10) Confidence 0.40 Published 1995 Journal J. Comp. Neurol. Section Title Doc Link 7636023 Disease Relevance 0 Pain Relevance 0.29
Dopamine D1, D2 and mu-opioid receptors are co-expressed with adenylyl cyclase 5 and phosphodiesterase 7B mRNAs in striatal rat cells.
Gene_expression (expressed) of D2 associated with dopamine and mu opioid receptor
11) Confidence 0.39 Published 2010 Journal Brain Res. Section Title Doc Link 19913519 Disease Relevance 0 Pain Relevance 0.19
This was true for both arc 1 (D1 and C1) whiskers, and arc 2 (D2 and C2) whiskers.
Gene_expression (whiskers) of D2 in whiskers associated with aids-related complex
12) Confidence 0.37 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2525689 Disease Relevance 0.33 Pain Relevance 0
The obtained results suggest that in the nucleus accumbens and striatum there is an opposite regulation between PENK and D2 receptor gene expression a short time after single and chronic cocaine administration.
Gene_expression (expression) of D2 in striatum associated with nucleus accumbens and cocaine
13) Confidence 0.35 Published 1995 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 8998398 Disease Relevance 0 Pain Relevance 0.57
These data imply that dopamine in the nucleus accumbens may act on each population of efferent neurons via the co-expression of two distinct dopamine receptors (D1+D3 or D2+D3), and that synergistic D1-like/D2-like effects may occur at the level of a single neuron, through the co-expression of D1 and D3 receptors in a significant proportion of substance P neurons (16% or 26% in the core and shell regions, respectively.
Gene_expression (co-expression) of D2 in neuron associated with nucleus accumbens, dopamine, dopamine receptor and substance p
14) Confidence 0.34 Published 1996 Journal Neuroscience Section Abstract Doc Link 8783237 Disease Relevance 0 Pain Relevance 0.63
In addition, comparison with D1 and D2 receptor gene expression was performed to study the potential co-localization of several dopamine receptors within the same neurons in the ventral striatum.
Gene_expression (expression) of D2 in ventral associated with dopamine receptor
15) Confidence 0.34 Published 1996 Journal Neuroscience Section Abstract Doc Link 8783237 Disease Relevance 0 Pain Relevance 0.51
This measurement was performed for the D1 and D2 whiskers in three rats (N6: 89–103 trials per texture, H1: 52–56 trials per texture, and H2: 40–43 trials per texture).
Gene_expression (whiskers) of D2 in whiskers
16) Confidence 0.32 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2525689 Disease Relevance 0 Pain Relevance 0.13
We repeated this analysis for ten whiskers (five D1 whiskers, four D2 whiskers, and one D3 whisker) in five rats (N4–N6, H1, and H2).
Gene_expression (whiskers) of D2 in whisker
17) Confidence 0.32 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2525689 Disease Relevance 0 Pain Relevance 0
In rat N2, the D2 and D1 whiskers were trimmed by approximately 2 mm after each day's measurement, while ?
Gene_expression (whiskers) of D2 in whiskers
18) Confidence 0.32 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2525689 Disease Relevance 0.07 Pain Relevance 0
The average kinematics of slips and sticks during protraction and retraction are shown in Figure 10D, for the D2 whisker in rat H1 moving across four sandpapers.
Gene_expression (whisker) of D2 in whisker
19) Confidence 0.32 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2525689 Disease Relevance 0 Pain Relevance 0
Across all textures, the high-frequency peak for D1 whiskers was found to be between 57.7 and 91.2 Hz (mean: 71.8 Hz); for D2 whiskers, 68.5–114.0 Hz (mean: 86.6 Hz); for the single D3 whisker, 142.2–153.9 Hz (mean: 147.9 Hz) (Figure 8A).
Gene_expression (whiskers) of D2 in whiskers
20) Confidence 0.32 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2525689 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox