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Context Info
Confidence 0.46
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.96
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ak1) cytoplasm (Ak1)
Anatomy Link Frequency
blood 1
musculature 1
Ak1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
halothane 9 99.52 Very High Very High Very High
Pain 4 92.24 High High
isoflurane 1 89.12 High High
ischemia 1 70.12 Quite High
anesthesia 2 66.72 Quite High
adenocard 2 59.20 Quite High
fibrosis 4 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 2 97.36 Very High Very High Very High
Arterial Occlusive Diseases 1 96.28 Very High Very High Very High
Increased Venous Pressure Under Development 4 92.76 High High
Pain 3 92.24 High High
Hepatitis Virus Infection 1 77.60 Quite High
Emergencies 1 77.60 Quite High
Peripheral Arterial Disease 3 75.00 Quite High
Injury 8 74.68 Quite High
Cv Unclassified Under Development 1 70.12 Quite High
Cirrhosis 6 14.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results give evidence for marked activation of the creatine kinase reaction, of glycolysis, of the myokinase reaction and of the purine nucleotide cycle in the ischaemic musculature at loads of short duration, which are in total sufficient to maintain the concentration of ATP even during claudication pain.
Positive_regulation (activation) of myokinase in musculature associated with pain and increased venous pressure under development
1) Confidence 0.46 Published 1989 Journal VASA Section Abstract Doc Link 2678801 Disease Relevance 0.41 Pain Relevance 0.16
The behaviour of both the directly and indirectly measured metabolites permits the deduction of activation of the creatine kinase reaction, glycolysis, myokinase reaction and the purine nucleotide cycle during exercise-induced hypoxia in the presence of arterial occlusive disease.
Positive_regulation (activation) of myokinase associated with arterial occlusive diseases and hypoxia
2) Confidence 0.46 Published 1989 Journal Klin. Wochenschr. Section Abstract Doc Link 2796250 Disease Relevance 0.32 Pain Relevance 0.11
Halothane rapidly and reversibly activated hepatic cytosolic glutathione S-transferases and purified isoenzyme 1-2 but not isoenzymes 1-1 and 3-3.
Positive_regulation (activated) of isoenzyme 1-2 associated with halothane
3) Confidence 0.03 Published 1988 Journal Biochem. Pharmacol. Section Abstract Doc Link 3377798 Disease Relevance 0 Pain Relevance 0.40
Treatment with a combination of L-carnitine and coenzyme Q10 (prior to CCl4 injection) resulted in a significant increase in isoenzyme 4 and a significant decrease in isoenzyme 1, isoenzyme 2, isoenzyme 3 and isoenzyme 5.
Positive_regulation (increase) of isoenzyme 1
4) Confidence 0.02 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.22 Pain Relevance 0.04
To assess the clinical effectiveness of intermittent warm cardioplegia, we measured the release of troponin-T (Tn-T), a highly sensitive and specific marker of myocardial damage, and creatine kinase MB isoenzyme (CK-MB), in 12 patients who underwent elective coronary artery bypass grafting (CABG) with antegrade intermittent warm blood cardioplegia (37 degrees C) being the warm group, in comparison with 16 patients who underwent CABG with antegrade intermittent cold blood cardioplegia (4 degrees C) being the cold group.
Positive_regulation (measured) of kinase MB isoenzyme in blood
5) Confidence 0.01 Published 1999 Journal Surg. Today Section Abstract Doc Link 10211562 Disease Relevance 0 Pain Relevance 0.07

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