INT278321

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Context Info
Confidence 0.14
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.67
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsb) mitochondrion (Ctsb) extracellular space (Ctsb)
extracellular region (Ctsb) lysosome (Ctsb) cytoplasm (Ctsb)
Anatomy Link Frequency
monocytes 1
Spleen 1
Ctsb (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 40 56.32 Quite High
cytokine 50 5.00 Very Low Very Low Very Low
Inflammatory response 20 5.00 Very Low Very Low Very Low
chemokine 15 5.00 Very Low Very Low Very Low
Inflammatory mediators 10 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rupture 15 99.24 Very High Very High Very High
Apoptosis 10 97.72 Very High Very High Very High
INFLAMMATION 70 56.32 Quite High
Disease 30 55.28 Quite High
Plasmodium Infection 85 46.56 Quite Low
Parasitemia 20 27.20 Quite Low
Infection 45 5.00 Very Low Very Low Very Low
Fever 30 5.00 Very Low Very Low Very Low
Crystal Associated Disease 10 5.00 Very Low Very Low Very Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Release of cathepsin B without lysosomal rupture has been observed in monocytes treated with the potassium ionophore nigericin [24].
Localization (Release) of cathepsin B in monocytes associated with rupture
1) Confidence 0.14 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.28 Pain Relevance 0
Another interesting observation is that Hz-activated cathepsin B occurred in the intracellular compartment and is rapidly quenched (1–3 hours), suggesting either a transient activation or cathepsin B release into the cytosol.
Localization (release) of cathepsin B
2) Confidence 0.14 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
In addition, the widely expressed Spleen Tyrosine Kinase (Syk) was shown to be required for cathepsin B release into the cytosol in a model of B cell receptor-mediated apoptosis [25].
Localization (release) of cathepsin B in Spleen associated with apoptosis
3) Confidence 0.14 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.28 Pain Relevance 0
First, we tested if Hz can induce release of the active form of cathepsin B in the supernatant and as showed in the Figure 9A, Hz did not induce cathepsin B release into supernatant as has been observed with MSU and silica.
Localization (release) of cathepsin B
4) Confidence 0.13 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.11 Pain Relevance 0.03
First, we tested if Hz can induce release of the active form of cathepsin B in the supernatant and as showed in the Figure 9A, Hz did not induce cathepsin B release into supernatant as has been observed with MSU and silica.
Localization (release) of cathepsin B
5) Confidence 0.13 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0

General Comments

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